6E67
Structure of beta2 adrenergic receptor fused to a Gs peptide
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Beta-2 adrenergic receptor,Endolysin,Guanine nucleotide-binding protein G(s) subunit alpha isoforms short,Beta-2 adrenergic receptor chimera | polymer | 531 | 60158.5 | 2 | UniProt (P07550) UniProt (A0A097J809) UniProt (P63092) Pfam (PF00001) Pfam (PF00959) In PDB | Homo sapiens (Human) | Beta-2 adrenoreceptor,Beta-2 adrenoceptor,Lysis protein,Lysozyme,Muramidase,Adenylate cyclase-stimulating G alpha protein,Beta-2 adrenoreceptor,Beta-2 adrenoceptor |
2 | A, B | 8-[(1R)-2-{[1,1-dimethyl-2-(2-methylphenyl)ethyl]amino}-1-hydroxyethyl]-5-hydroxy-2H-1,4-benzoxazin-3(4H)-one | non-polymer | 370.4 | 2 | Chemie (P0G) |
Sequence modifications
A, B: 1 - 232 (UniProt: P07550)
A, B: 1002 - 1161 (UniProt: A0A097J809)
A, B: 2381 - 2394 (UniProt: P63092)
A, B: 268 - 365 (UniProt: P07550)
PDB | External Database | Details |
---|---|---|
Met -23 | - | expression tag |
Lys -22 | - | expression tag |
Thr -21 | - | expression tag |
Ile -20 | - | expression tag |
Ile -19 | - | expression tag |
Ala -18 | - | expression tag |
Leu -17 | - | expression tag |
Ser -16 | - | expression tag |
Tyr -15 | - | expression tag |
Ile -14 | - | expression tag |
Phe -13 | - | expression tag |
Cys -12 | - | expression tag |
Leu -11 | - | expression tag |
Val -10 | - | expression tag |
Phe -9 | - | expression tag |
Ala -8 | - | expression tag |
Asp -7 | - | expression tag |
Tyr -6 | - | expression tag |
Lys -5 | - | expression tag |
Asp -4 | - | expression tag |
Asp -3 | - | expression tag |
Asp -2 | - | expression tag |
Asp -1 | - | expression tag |
Ala 0 | - | expression tag |
Arg 16 | Gly 16 | variant |
Gln 27 | Glu 27 | variant |
Thr 96 | Met 96 | engineered mutation |
Thr 98 | Met 98 | engineered mutation |
Glu 187 | Asn 187 | engineered mutation |
Cys 226 | Ala 226 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Thr 1054 | Cys 54 | engineered mutation |
Ala 1097 | Cys 97 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Cys 2394 | Leu 394 | linker |
Gly 3001 | - | linker |
Thr 3002 | - | linker |
Gly 3003 | - | linker |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 120317.1 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 740.9 | |
All* | Total formula weight | 121058.0 |