7YMJ

Cryo-EM structure of alpha1AAR-Nb6 complex bound to tamsulosin

Summary for 7YMJ

• Entry DOI: 10.2210/pdb7ymj/pdb
• Related: 7YM8 7YMH
• EMDB information: 33924 33928 33930
• Descriptor: alpha1A-adrenergic receptor, Nb6, Tamsulosin (3 entities in total)
• Functional Keywords: gpcr, nanobody, antagonist, complex, membrane protein
• Biological source: Homo sapiens; More
• Total number of polymer chains: 2
• Total formula weight: 57728.28

Authors

Toyoda, Y.,Zhu, A.,Yan, C.,Kobilka, B.K.,Liu, X. (deposition date: 2022-07-28, release date: 2023-07-05)

• Primary citation: Toyoda, Y.,Zhu, A.,Kong, F.,Shan, S.,Zhao, J.,Wang, N.,Sun, X.,Zhang, L.,Yan, C.,Kobilka, B.K.,Liu, X.; Structural basis of alpha 1A -adrenergic receptor activation and recognition by an extracellular nanobody.; Nat Commun, 14:3655-3655, 2023; PubMed: 37339967; DOI: 10.1038/s41467-023-39310-x

Experimental method

ELECTRON MICROSCOPY (3.35 Å)