5UIG

Crystal structure of adenosine A2A receptor bound to a novel triazole-carboximidamide antagonist

Summary for 5UIG

Entry DOI	10.2210/pdb5uig/pdb
Descriptor	Adenosine receptor A2a,Soluble cytochrome b562,Adenosine receptor A2a, {[-(BIS-CARBOXYMETHYL-AMINO)-ETHYL]-CARBOXYMETHYL-AMINO}-ACETIC ACID, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ... (4 entities in total)
Functional Keywords	adenosine, a2a receptor, gpcr, vapor diffusion, allosteric, parkinson's disease, adenosine binding protein
Biological source	Homo sapiens (Human) More
Cellular location	Cell membrane; Multi-pass membrane protein: P29274
Total number of polymer chains	1
Total formula weight	50364.75
Authors	Sun, B.,Bachhawat, P.,Ling-Hon Chu, M.,Ceska, T.,Sands, Z.,Lebon, F.,Kobilka, T.S.,Kobilka, B. (deposition date: 2017-01-13, release date: 2017-02-08, Last modification date: 2023-10-04)
Primary citation	Sun, B.,Bachhawat, P.,Chu, M.L.,Wood, M.,Ceska, T.,Sands, Z.A.,Mercier, J.,Lebon, F.,Kobilka, T.S.,Kobilka, B.K. Crystal structure of the adenosine A2A receptor bound to an antagonist reveals a potential allosteric pocket. Proc. Natl. Acad. Sci. U.S.A., 114:2066-2071, 2017 Cited by PubMed: 28167788 DOI: 10.1073/pnas.1621423114 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.5 Å)

Structure validation