7YM8

Cryo-EM structure of Nb29-alpha1AAR-miniGsq complex bound to oxymetazoline

Summary for 7YM8

Entry DOI	10.2210/pdb7ym8/pdb
EMDB information	33924
Descriptor	miniGsq, alpha1A adrenergic receptor, nanobody 29, ... (5 entities in total)
Functional Keywords	gpcr, nanobody, agonist, complex, membrane protein
Biological source	Homo sapiens More
Total number of polymer chains	3
Total formula weight	98870.89
Authors	Toyoda, Y.,Zhu, A.,Yan, C.,Kobilka, B.K.,Liu, X. (deposition date: 2022-07-27, release date: 2023-07-05)
Primary citation	Toyoda, Y.,Zhu, A.,Kong, F.,Shan, S.,Zhao, J.,Wang, N.,Sun, X.,Zhang, L.,Yan, C.,Kobilka, B.K.,Liu, X. Structural basis of alpha 1A -adrenergic receptor activation and recognition by an extracellular nanobody. Nat Commun, 14:3655-3655, 2023 Cited by PubMed: 37339967 DOI: 10.1038/s41467-023-39310-x PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (2.92 Å)

Structure validation