3P0G

Structure of a nanobody-stabilized active state of the beta2 adrenoceptor

Summary for 3P0G

DescriptorBeta-2 adrenergic receptor, Lysozyme, Camelid Antibody Fragment, 8-[(1R)-2-{[1,1-dimethyl-2-(2-methylphenyl)ethyl]amino}-1-hydroxyethyl]-5-hydroxy-2H-1,4-benzoxazin-3(4H)-one (3 entities in total)
Functional Keywordsbeta-2 adrenoceptor, agonist, nanobody, 7tm, gpcr, membrane, signaling protein, hydrolase, membrane protein
Biological sourceHomo sapiens (human, Bacteriophage T4)
More
Cellular locationCell membrane ; Multi- pass membrane protein  P07550
Total number of polymer chains2
Total molecular weight70871.15
Authors
Primary citation
Rasmussen, S.G.,Choi, H.J.,Fung, J.J.,Pardon, E.,Casarosa, P.,Chae, P.S.,Devree, B.T.,Rosenbaum, D.M.,Thian, F.S.,Kobilka, T.S.,Schnapp, A.,Konetzki, I.,Sunahara, R.K.,Gellman, S.H.,Pautsch, A.,Steyaert, J.,Weis, W.I.,Kobilka, B.K.
Structure of a nanobody-stabilized active state of the b2 adrenoceptor
Nature, 469:175-180, 2011
PubMed: 21228869 (PDB entries with the same primary citation)
DOI: 10.1038/nature09648
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (3.5 Å)
NMR Information
?

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.255111.8%17.2%0.7%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 3p0g
no rotation
Molmil generated image of 3p0g
rotated about x axis by 90°
Molmil generated image of 3p0g
rotated about y axis by 90°
PDBj@FacebookPDBj@TwitterwwPDBwwPDB Foundation

Copyright © 2013-2019 Protein Data Bank Japan