6XOX

cryo-EM of human GLP-1R bound to non-peptide agonist LY3502970

Summary for 6XOX

• Entry DOI: 10.2210/pdb6xox/pdb
• EMDB information: 22283
• Descriptor: Alpha subunit of Gs with N-terminus swapped with equivalent residues in Gi,Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, single-chain variable fragment scFv16, ... (7 entities in total)
• Functional Keywords: class b gpcr, glucagon-like peptide-1 receptor, g protein nucleotide exchange factor., membrane protein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 6
• Total formula weight: 187033.91

Authors

Sun, B.,Kobilka, B.K.,Sloop, K.W.,Feng, D.,Kobilka, T.S. (deposition date: 2020-07-07, release date: 2020-11-18, Last modification date: 2020-12-09)

• Primary citation: Kawai, T.,Sun, B.,Yoshino, H.,Feng, D.,Suzuki, Y.,Fukazawa, M.,Nagao, S.,Wainscott, D.B.,Showalter, A.D.,Droz, B.A.,Kobilka, T.S.,Coghlan, M.P.,Willard, F.S.,Kawabe, Y.,Kobilka, B.K.,Sloop, K.W.; Structural basis for GLP-1 receptor activation by LY3502970, an orally active nonpeptide agonist.; Proc.Natl.Acad.Sci.USA, 117:29959-29967, 2020; PubMed: 33177239; DOI: 10.1073/pnas.2014879117

Experimental method

ELECTRON MICROSCOPY (3.1 Å)