4MQT
Structure of active human M2 muscarinic acetylcholine receptor bound to the agonist iperoxo and allosteric modulator LY2119620
Summary for 4MQT
Entry DOI | 10.2210/pdb4mqt/pdb |
Related | 3UON 4MQS |
Descriptor | Muscarinic acetylcholine receptor M2, Nanobody 9-8, 4-(4,5-dihydro-1,2-oxazol-3-yloxy)-N,N,N-trimethylbut-2-yn-1-aminium, ... (4 entities in total) |
Functional Keywords | g protein-coupled receptor, muscarinic acetylcholine receptor, allosteric modulation, signaling protein |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 2 |
Total formula weight | 54015.33 |
Authors | Kruse, A.C.,Ring, A.M.,Manglik, A.,Hu, J.,Hu, K.,Eitel, K.,Huebner, H.,Pardon, E.,Valant, C.,Sexton, P.M.,Christopoulos, A.,Felder, C.C.,Gmeiner, P.,Steyaert, J.,Weis, W.I.,Garcia, K.C.,Wess, J.,Kobilka, B.K. (deposition date: 2013-09-16, release date: 2013-11-27, Last modification date: 2023-09-20) |
Primary citation | Kruse, A.C.,Ring, A.M.,Manglik, A.,Hu, J.,Hu, K.,Eitel, K.,Hubner, H.,Pardon, E.,Valant, C.,Sexton, P.M.,Christopoulos, A.,Felder, C.C.,Gmeiner, P.,Steyaert, J.,Weis, W.I.,Garcia, K.C.,Wess, J.,Kobilka, B.K. Activation and allosteric modulation of a muscarinic acetylcholine receptor. Nature, 504:101-106, 2013 Cited by PubMed: 24256733DOI: 10.1038/nature12735 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.7 Å) |
Structure validation
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