4DKL
Crystal structure of the mu-opioid receptor bound to a morphinan antagonist
Summary for 4DKL
Entry DOI | 10.2210/pdb4dkl/pdb |
Descriptor | Mu-type opioid receptor, lysozyme chimera, methyl 4-{[(5beta,6alpha)-17-(cyclopropylmethyl)-3,14-dihydroxy-4,5-epoxymorphinan-6-yl]amino}-4-oxobutanoate, SULFATE ION, ... (8 entities in total) |
Functional Keywords | g-protein coupled receptor, 7 transmembrane receptor, signaling protein-antagonist complex, signaling protein/antagonist |
Biological source | Mus musculus (mouse, bacteriophage T4) More |
Cellular location | Cell membrane ; Multi- pass membrane protein : P42866 |
Total number of polymer chains | 1 |
Total formula weight | 55761.67 |
Authors | Manglik, A.,Kruse, A.C.,Kobilka, T.S.,Thian, F.S.,Mathiesen, J.M.,Sunahara, R.K.,Pardo, L.,Weis, W.I.,Kobilka, B.K.,Granier, S. (deposition date: 2012-02-03, release date: 2012-03-21, Last modification date: 2023-09-13) |
Primary citation | Manglik, A.,Kruse, A.C.,Kobilka, T.S.,Thian, F.S.,Mathiesen, J.M.,Sunahara, R.K.,Pardo, L.,Weis, W.I.,Kobilka, B.K.,Granier, S. Crystal structure of the {mu}-opioid receptor bound to a morphinan antagonist. Nature, 485:321-326, 2012 Cited by PubMed: 22437502DOI: 10.1038/nature10954 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
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