4DKL

Crystal structure of the mu-opioid receptor bound to a morphinan antagonist

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Mu-type opioid receptor, lysozyme chimera	polymer	464	52778.9	1	UniProt (P42866) UniProt (P00720) Pfam (PF00001) Pfam (PF00959) In PDB	Mus musculus (mouse bacteriophage T4)	Mu-opioid receptor, M-OR-1, MOR-1, Endolysin, Lysis protein, Muramidase
2	A	methyl 4-{[(5beta,6alpha)-17-(cyclopropylmethyl)-3,14-dihydroxy-4,5-epoxymorphinan-6-yl]amino}-4-oxobutanoate	non-polymer		456.5	1	Chemie (BF0)
3	A	SULFATE ION	non-polymer		96.1	12	Chemie (SO4)
4	A	CHOLESTEROL	non-polymer		386.7	1	Chemie (CLR)
5	A	[(Z)-octadec-9-enyl] (2R)-2,3-bis(oxidanyl)propanoate	non-polymer		356.5	2	Chemie (MPG)
6	A	PENTAETHYLENE GLYCOL	non-polymer		238.3	1	Chemie (1PE)
7	A	CHLORIDE ION	non-polymer		35.5	1	Chemie (CL)
8		water	water		18.0	37	Chemie (HOH)

Sequence modifications

A: 52 - 263 (UniProt: P42866)
A: 1002 - 1161 (UniProt: P00720)

PDB	External Database	Details
Asn 1020	Asp 20	engineered mutation
Thr 1054	Cys 54	engineered mutation
Ala 1097	Cys 97	engineered mutation

A: 270 - 360 (UniProt: P42866)

PDB	External Database	Details
Pro 361	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	52778.9
Non-Polymers*	Number of molecules	18
	Total formula weight	2982.8
All*	Total formula weight	55761.7

*Water molecules are not included.