4DKL
Crystal structure of the mu-opioid receptor bound to a morphinan antagonist
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Mu-type opioid receptor, lysozyme chimera | polymer | 464 | 52778.9 | 1 | UniProt (P42866) UniProt (P00720) Pfam (PF00001) Pfam (PF00959) | Mus musculus (mouse bacteriophage T4) | Mu-opioid receptor, M-OR-1, MOR-1, Endolysin, Lysis protein, Muramidase |
| 2 | B (A) | methyl 4-{[(5beta,6alpha)-17-(cyclopropylmethyl)-3,14-dihydroxy-4,5-epoxymorphinan-6-yl]amino}-4-oxobutanoate | non-polymer | 456.5 | 1 | Chemie (BF0) | |||
| 3 | C, D, E, F, G... (A) | SULFATE ION | non-polymer | 96.1 | 12 | Chemie (SO4) | |||
| 4 | O (A) | CHOLESTEROL | non-polymer | 386.7 | 1 | Chemie (CLR) | |||
| 5 | P, Q (A) | [(Z)-octadec-9-enyl] (2R)-2,3-bis(oxidanyl)propanoate | non-polymer | 356.5 | 2 | Chemie (MPG) | |||
| 6 | R (A) | PENTAETHYLENE GLYCOL | non-polymer | 238.3 | 1 | Chemie (1PE) | |||
| 7 | S (A) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 8 | T (A) | water | water | 18.0 | 37 | Chemie (HOH) |
Sequence modifications
A: 52 - 263 (UniProt: P42866)
A: 1002 - 1161 (UniProt: P00720)
A: 270 - 360 (UniProt: P42866)
A: 1002 - 1161 (UniProt: P00720)
| PDB | External Database | Details |
|---|---|---|
| Asn 1020 | Asp 20 | engineered mutation |
| Thr 1054 | Cys 54 | engineered mutation |
| Ala 1097 | Cys 97 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Pro 361 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 52778.9 | |
| Non-Polymers* | Number of molecules | 18 |
| Total formula weight | 2982.8 | |
| All* | Total formula weight | 55761.7 |
