4DKL

Crystal structure of the mu-opioid receptor bound to a morphinan antagonist

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003796	molecular_function	lysozyme activity
A	0003824	molecular_function	catalytic activity
A	0004930	molecular_function	G protein-coupled receptor activity
A	0007186	biological_process	G protein-coupled receptor signaling pathway
A	0008152	biological_process	metabolic process
A	0009253	biological_process	peptidoglycan catabolic process
A	0016020	cellular_component	membrane
A	0016787	molecular_function	hydrolase activity
A	0016798	molecular_function	hydrolase activity, acting on glycosyl bonds
A	0016998	biological_process	cell wall macromolecule catabolic process
A	0030430	cellular_component	host cell cytoplasm
A	0031640	biological_process	killing of cells of another organism
A	0042742	biological_process	defense response to bacterium
A	0044659	biological_process	viral release from host cell by cytolysis

Functional Information from PDB Data

site_id	AC1
Number of Residues	13
Details	BINDING SITE FOR RESIDUE BF0 A 601

Chain	Residue
A	ASP147
A	TRP318
A	ILE322
A	TYR326
A	HOH718
A	TYR148
A	MET151
A	GLU229
A	LYS233
A	VAL236
A	TRP293
A	ILE296
A	VAL300

---

site_id	AC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 A 602

Chain	Residue
A	THR101
A	ALA102
A	THR103
A	ARG179
A	ILE278
A	HOH701
A	HOH712

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 603

Chain	Residue
A	ASN137
A	LYS141
A	THR207
A	ARG1119

---

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 A 604

Chain	Residue
A	HIS171
A	PRO172
A	VAL173
A	LYS174
A	GLY1012
A	LEU1013

---

site_id	AC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 A 605

Chain	Residue
A	ARG1014
A	LEU1015
A	LYS1016

---

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 606

Chain	Residue
A	HIS223
A	PRO224
A	THR225
A	TRP226

---

site_id	AC7
Number of Residues	9
Details	BINDING SITE FOR RESIDUE SO4 A 607

Chain	Residue
A	HIS223
A	HOH714
A	HOH722
A	GLY1113
A	PHE1114
A	THR1115
A	ASN1116
A	SER1117
A	ASN1132

---

site_id	AC8
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 A 608

Chain	Residue
A	HOH714
A	ARG1137

---

site_id	AC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 A 609

Chain	Residue
A	PHE204
A	ARG1119
A	GLN1123

---

site_id	BC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 A 610

Chain	Residue
A	ARG277
A	ARG280

---

site_id	BC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 A 611

Chain	Residue
A	HIS171
A	ARG258
A	ARG1008
A	LEU1013
A	LYS1060

---

site_id	BC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 A 612

Chain	Residue
A	THR1142
A	ASN1144
A	ARG1145

---

site_id	BC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 A 613

Chain	Residue
A	ARG95
A	TYR96
A	THR97

---

site_id	BC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CLR A 614

Chain	Residue
A	TYR299
A	ILE302
A	ILE308
A	SER317
A	HOH731

---

site_id	BC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MPG A 615

Chain	Residue
A	PHE108
A	ASN109
A	LYS185
A	ASN188
A	TRP192

---

site_id	BC7
Number of Residues	10
Details	BINDING SITE FOR RESIDUE MPG A 616

Chain	Residue
A	MET72
A	MET72
A	ALA73
A	TYR75
A	SER76
A	SER76
A	CYS79
A	LEU83
A	PRO122
A	SER125

---

site_id	BC8
Number of Residues	10
Details	BINDING SITE FOR RESIDUE 1PE A 617

Chain	Residue
A	TRP226
A	TRP226
A	LYS303
A	LYS303
A	LEU305
A	LEU305
A	ILE306
A	ILE306
A	THR307
A	THR307

---

site_id	BC9
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL A 618

Chain	Residue
A	SER261
A	GLU270

---

Functional Information from PROSITE/UniProt

site_id	PS00237
Number of Residues	17
Details	G_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. TSIfTLCTMSVDRYIaV

Chain	Residue	Details
A	THR153-VAL169

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	24
Details	TRANSMEM: Helical; Name=1 => ECO:0000269|PubMed:22437502, ECO:0000269|PubMed:26245379

Chain	Residue	Details
A	THR67-TYR91

---

site_id	SWS_FT_FI2
Number of Residues	31
Details	TOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:22437502, ECO:0000269|PubMed:26245379

Chain	Residue	Details
A	VAL92-ASN104
A	ASP164-ASN183

---

site_id	SWS_FT_FI3
Number of Residues	24
Details	TRANSMEM: Helical; Name=2 => ECO:0000269|PubMed:22437502, ECO:0000269|PubMed:26245379

Chain	Residue	Details
A	ILE105-LEU129

---

site_id	SWS_FT_FI4
Number of Residues	39
Details	TOPO_DOM: Extracellular => ECO:0000269|PubMed:22437502, ECO:0000269|PubMed:26245379

Chain	Residue	Details
A	MET130-CYS140
A	ALA206-TRP228
A	LEU305-THR312

---

site_id	SWS_FT_FI5
Number of Residues	22
Details	TRANSMEM: Helical; Name=3 => ECO:0000269|PubMed:22437502, ECO:0000269|PubMed:26245379

Chain	Residue	Details
A	LYS141-VAL163

---

site_id	SWS_FT_FI6
Number of Residues	21
Details	TRANSMEM: Helical; Name=4 => ECO:0000269|PubMed:22437502, ECO:0000269|PubMed:26245379

Chain	Residue	Details
A	ALA184-MET205

---

site_id	SWS_FT_FI7
Number of Residues	24
Details	TRANSMEM: Helical; Name=5 => ECO:0000269|PubMed:22437502, ECO:0000269|PubMed:26245379

Chain	Residue	Details
A	GLU229-GLY253

---

site_id	SWS_FT_FI8
Number of Residues	26
Details	TRANSMEM: Helical; Name=6 => ECO:0000269|PubMed:22437502, ECO:0000269|PubMed:26245379

Chain	Residue	Details
A	ILE278-ALA304

---

site_id	SWS_FT_FI9
Number of Residues	23
Details	TRANSMEM: Helical; Name=7 => ECO:0000269|PubMed:22437502, ECO:0000269|PubMed:26245379

Chain	Residue	Details
A	PHE313-TYR336

---

site_id	SWS_FT_FI10
Number of Residues	1
Details	MOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:P33535

Chain	Residue	Details
A	TYR166

---

site_id	SWS_FT_FI11
Number of Residues	1
Details	LIPID: S-palmitoyl cysteine => ECO:0000255

Chain	Residue	Details
A	CYS351

---

site_id	SWS_FT_FI12
Number of Residues	1
Details	ACT_SITE: Proton donor/acceptor => ECO:0000255|HAMAP-Rule:MF_04110, ECO:0000269|PubMed:3382407, ECO:0000269|PubMed:7831309, ECO:0000269|PubMed:8266098

Chain	Residue	Details
A	GLU1011

---

site_id	SWS_FT_FI13
Number of Residues	1
Details	ACT_SITE: Proton donor/acceptor => ECO:0000255|HAMAP-Rule:MF_04110, ECO:0000269|PubMed:1892846, ECO:0000269|PubMed:3382407, ECO:0000269|PubMed:7831309, ECO:0000269|PubMed:8266098

Chain	Residue	Details
A	ASN1020

---

site_id	SWS_FT_FI14
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269|PubMed:8266098

Chain	Residue	Details
A	LEU1032
A	PHE1104

---

site_id	SWS_FT_FI15
Number of Residues	2
Details	BINDING: BINDING => ECO:0000303|PubMed:7831309

Chain	Residue	Details
A	SER1117
A	ASN1132

---

Catalytic Information from CSA

site_id	MCSA1
Number of Residues	2
Details	M-CSA 921

Chain	Residue	Details
A	GLU1011	proton shuttle (general acid/base)
A	ASN1020	covalent catalysis

---