5YCO
 
 | | Complex structure of PCNA with UHRF2 | | 分子名称: | E3 ubiquitin-protein ligase UHRF2, GLYCEROL, Proliferating cell nuclear antigen, ... | | 著者 | Wu, M, Chen, W, Hang, T, Wang, C, Zhang, X, Zang, J. | | 登録日 | 2017-09-07 | | 公開日 | 2017-11-15 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.199 Å) | | 主引用文献 | Structure insights into the molecular mechanism of the interaction between UHRF2 and PCNA.
Biochem. Biophys. Res. Commun., 494, 2017
|
|
3KCU
 | | Structure of formate channel | | 分子名称: | 2-(6-(2-CYCLOHEXYLETHOXY)-TETRAHYDRO-4,5-DIHYDROXY-2(HYDROXYMETHYL)-2H-PYRAN-3-YLOXY)-TETRAHYDRO-6(HYDROXYMETHYL)-2H-PY RAN-3,4,5-TRIOL, Probable formate transporter 1 | | 著者 | Wang, Y, Huang, Y, Wang, J, Yan, N, Shi, Y. | | 登録日 | 2009-10-22 | | 公開日 | 2009-12-01 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (2.243 Å) | | 主引用文献 | Structure of the formate transporter FocA reveals a pentameric aquaporin-like channel
Nature, 462, 2009
|
|
6N7X
 | | S. cerevisiae U1 snRNP | | 分子名称: | 56 kDa U1 small nuclear ribonucleoprotein component, Pre-mRNA-processing factor 39, Protein NAM8, ... | | 著者 | Li, X, Liu, S, Jiang, J, Zhang, L, Espinosa, S, Hill, R.C, Hansen, K.C, Zhou, Z.H, Zhao, R. | | 登録日 | 2018-11-28 | | 公開日 | 2019-07-24 | | 最終更新日 | 2024-03-13 | | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | | 主引用文献 | CryoEM structure of Saccharomyces cerevisiae U1 snRNP offers insight into alternative splicing.
Nat Commun, 8, 2017
|
|
6N9N
 | | Crystal structure of murine GSDMD | | 分子名称: | Gasdermin-D | | 著者 | Liu, Z, Wang, C, Yang, J, Xiao, T.S. | | 登録日 | 2018-12-03 | | 公開日 | 2019-06-05 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | | 主引用文献 | Crystal Structures of the Full-Length Murine and Human Gasdermin D Reveal Mechanisms of Autoinhibition, Lipid Binding, and Oligomerization.
Immunity, 51, 2019
|
|
6N9O
 | | Crystal structure of human GSDMD | | 分子名称: | Gasdermin-D | | 著者 | Liu, Z, Wang, C, Yang, J, Xiao, T.S. | | 登録日 | 2018-12-03 | | 公開日 | 2019-06-05 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (3.5 Å) | | 主引用文献 | Crystal Structures of the Full-Length Murine and Human Gasdermin D Reveal Mechanisms of Autoinhibition, Lipid Binding, and Oligomerization.
Immunity, 51, 2019
|
|
4XSJ
 | | Crystal structure of the N-terminal domain of the human mitochondrial calcium uniporter fused with T4 lysozyme | | 分子名称: | Lysozyme,Calcium uniporter protein, mitochondrial, SULFATE ION | | 著者 | Lee, Y, Min, C.K, Kim, T.G, Song, H.K, Lim, Y, Kim, D, Shin, K, Kang, M, Kang, J.Y, Youn, H.-S, Lee, J.-G, An, J.Y, Park, K.R, Lim, J.J, Kim, J.H, Kim, J.H, Park, Z.Y, Kim, Y.-S, Wang, J, Kim, D.H, Eom, S.H. | | 登録日 | 2015-01-22 | | 公開日 | 2015-09-16 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Structure and function of the N-terminal domain of the human mitochondrial calcium uniporter.
Embo Rep., 16, 2015
|
|
4XTB
 | | Crystal structure of the N-terminal domain of the human mitochondrial calcium uniporter | | 分子名称: | Calcium uniporter protein, mitochondrial, TETRAETHYLENE GLYCOL | | 著者 | Lee, Y, Min, C.K, Kim, T.G, Song, H.K, Lim, Y, Kim, D, Shin, K, Kang, M, Kang, J.Y, Youn, H.-S, Lee, J.-G, An, J.Y, Park, K.R, Lim, J.J, Kim, J.H, Kim, J.H, Park, Z.Y, Kim, Y.-S, Wang, J, Kim, D.H, Eom, S.H. | | 登録日 | 2015-01-23 | | 公開日 | 2015-09-16 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Structure and function of the N-terminal domain of the human mitochondrial calcium uniporter.
Embo Rep., 16, 2015
|
|
3KCV
 | | Structure of formate channel | | 分子名称: | Probable formate transporter 1 | | 著者 | Wang, Y, Huang, Y, Wang, J, Yan, N, Shi, Y. | | 登録日 | 2009-10-22 | | 公開日 | 2009-12-01 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (3.198 Å) | | 主引用文献 | Structure of the formate transporter FocA reveals a pentameric aquaporin-like channel
Nature, 462, 2009
|
|
5HUK
 | | The crystal structure of neuraminidase from A/Northern pintail/Washington/40964/2014 influenza virus | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | | 著者 | Yang, H, Carney, P.J, Guo, Z, Chang, J.C, Stevens, J. | | 登録日 | 2016-01-27 | | 公開日 | 2016-04-13 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (2.45 Å) | | 主引用文献 | Molecular Characterizations of Surface Proteins Hemagglutinin and Neuraminidase from Recent H5Nx Avian Influenza Viruses.
J.Virol., 90, 2016
|
|
8GHS
 | | Empty HBV Cp183 capsid with importin-beta, subparticle reconstruction at 2-fold location | | 分子名称: | Capsid protein | | 著者 | Kim, C, Schlicksup, C.J, Hadden-Perilla, J.A, Wang, J.C.-Y, Zlotnick, A. | | 登録日 | 2023-03-10 | | 公開日 | 2023-08-09 | | 最終更新日 | 2023-09-06 | | 実験手法 | ELECTRON MICROSCOPY (4 Å) | | 主引用文献 | Structure of the Hepatitis B virus capsid quasi-6-fold with a trapped C-terminal domain reveals capsid movements associated with domain exit.
J.Biol.Chem., 299, 2023
|
|
4GUU
 | | Crystal structure of LSD2-NPAC with tranylcypromine | | 分子名称: | Lysine-specific histone demethylase 1B, Putative oxidoreductase GLYR1, ZINC ION, ... | | 著者 | Chen, F, Dong, Z, Fang, J, Yang, Y, Li, Z, Xu, Y, Yang, H, Wang, P, Xu, Y. | | 登録日 | 2012-08-29 | | 公開日 | 2013-01-16 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.302 Å) | | 主引用文献 | LSD2/KDM1B and its cofactor NPAC/GLYR1 endow a structural and molecular model for regulation of H3K4 demethylation
Mol.Cell, 49, 2013
|
|
4APP
 | | Crystal Structure of the Human p21-Activated Kinase 4 in Complex with (S)-N-(5-(3-benzyl-1-methylpiperazine-4-carbonyl)-6,6-dimethyl-1,4,5, 6-tetrahydropyrrolo(3,4-c)pyrazol-3-yl)-3-phenoxybenzamide | | 分子名称: | GLYCEROL, N-[6,6-dimethyl-5-[(2S)-4-methyl-2-(phenylmethyl)piperazin-1-yl]carbonyl-2,4-dihydropyrrolo[3,4-c]pyrazol-3-yl]-3-phenoxy-benzamide, SERINE/THREONINE-PROTEIN KINASE PAK 4 | | 著者 | Knighton, D.D, Deng, Y.L, Wang, C, Guo, C, McAlpine, I, Zhang, J, Kephart, S, Johnson, M.C, Li, H, Bouzida, D, Yang, A, Dong, L, Marakovits, J, Tikhe, J, Richardson, P, Guo, L.C, Kania, R, Edwards, M.P, Kraynov, E, Christensen, J, Piraino, J, Lee, J, Dagostino, E, Del-Carmen, C, Smeal, T, Murray, B.W. | | 登録日 | 2012-04-04 | | 公開日 | 2012-06-06 | | 最終更新日 | 2019-05-08 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Discovery of Pyrroloaminopyrazoles as Novel Pak Inhibitors.
J.Med.Chem., 55, 2012
|
|
4GY5
 | | Crystal structure of the tandem tudor domain and plant homeodomain of UHRF1 with Histone H3K9me3 | | 分子名称: | E3 ubiquitin-protein ligase UHRF1, Peptide from Histone H3.3, ZINC ION | | 著者 | Cheng, J, Yang, Y, Fang, J, Xiao, J, Zhu, T, Chen, F, Wang, P, Xu, Y. | | 登録日 | 2012-09-05 | | 公開日 | 2012-11-14 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.956 Å) | | 主引用文献 | Structural insight into coordinated recognition of trimethylated histone H3 lysine 9 (H3K9me3) by the plant homeodomain (PHD) and tandem tudor domain (TTD) of UHRF1 (ubiquitin-like, containing PHD and RING finger domains, 1) protein
J.Biol.Chem., 288, 2013
|
|
7CRW
 | | Cryo-EM structure of rNLRP1-rDPP9 complex | | 分子名称: | Dipeptidyl peptidase 9, NLR family protein 1 | | 著者 | Huang, M.H, Zhang, X.X, Wang, J, Chai, J.J. | | 登録日 | 2020-08-14 | | 公開日 | 2021-03-24 | | 最終更新日 | 2024-03-27 | | 実験手法 | ELECTRON MICROSCOPY (3.18 Å) | | 主引用文献 | Structural and biochemical mechanisms of NLRP1 inhibition by DPP9.
Nature, 592, 2021
|
|
7CRV
 | |
6K8O
 | | Crystal structure of the Sulfolobus solfataricus topoisomerase III in complex with DNA | | 分子名称: | DNA (5'-D(*GP*CP*AP*AP*GP*GP*TP*C)-3'), ZINC ION, topoisomerase III | | 著者 | Wang, H.Q, Zhang, J.H, Zheng, X, Zheng, Z.F, Dong, Y.H, Huang, L, Gong, Y. | | 登録日 | 2019-06-13 | | 公開日 | 2020-06-24 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Crystal structures of the Sulfolobus solfataricus topoisomerase III reveal that its C-terminal novel zinc finger part is a unique decatenation domain
To Be Published
|
|
3GGQ
 | | Dimerization of Hepatitis E Virus Capsid Protein E2s Domain is Essential for Virus-Host Interaction | | 分子名称: | BROMIDE ION, Capsid protein | | 著者 | Li, S.W, Tang, X.H, Seetharaman, J, Yang, C.Y, Gu, Y, Zhang, J, Du, H.L, Shih, J.W.K, Hew, C.L, Sivaraman, J, Xia, N.S. | | 登録日 | 2009-03-02 | | 公開日 | 2009-08-25 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Dimerization of hepatitis E virus capsid protein E2s domain is essential for virus-host interaction
Plos Pathog., 5, 2009
|
|
4NTJ
 | | Structure of the human P2Y12 receptor in complex with an antithrombotic drug | | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, CHOLESTEROL, P2Y purinoceptor 12,Soluble cytochrome b562,P2Y purinoceptor 12, ... | | 著者 | Zhang, K, Zhang, J, Gao, Z.-G, Zhang, D, Zhu, L, Han, G.W, Moss, S.M, Paoletta, S, Kiselev, E, Lu, W, Fenalti, G, Zhang, W, Muller, C.E, Yang, H, Jiang, H, Cherezov, V, Katritch, V, Jacobson, K.A, Stevens, R.C, Wu, B, Zhao, Q, GPCR Network (GPCR) | | 登録日 | 2013-12-02 | | 公開日 | 2014-03-26 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.62 Å) | | 主引用文献 | Structure of the human P2Y12 receptor in complex with an antithrombotic drug
Nature, 509, 2014
|
|
3ROV
 | | Insulin's biosynthesis and activity have opposing structural requirements: a new factor in neonatal diabetes mellitus | | 分子名称: | CHLORIDE ION, Insulin, PHENOL, ... | | 著者 | Weiss, M.A, Wan, Z.L, Dodson, E.J, Liu, M, Xu, B, Hua, Q.X, Turkenburg, M, Whittingham, J, Nakagawa, S.H, Huang, K, Hu, S.Q, Jia, W.H, Wang, S.H, Brange, J, Whittaker, J, Arvan, P, Katsoyannis, P.G, Dodson, G.G. | | 登録日 | 2011-04-26 | | 公開日 | 2012-05-02 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Insulin's biosynthesis and activity have opposing structural requirements: a new factor in neonatal diabetes mellitus
To be Published
|
|
3AUV
 | | Predicting Amino Acid Preferences in the Complementarity Determining Regions of an Antibody-Antigen Recognition Interface | | 分子名称: | sc-dsFv derived from the G6-Fab | | 著者 | Yu, C.M, Peng, H.P, Chen, I.C, Lee, Y.C, Chen, J.B, Tsai, K.C, Chen, C.T, Chang, J.Y, Yang, E.W, Hsu, P.C, Jian, J.W, Hsu, H.J, Chang, H.J, Hsu, W.L, Huang, K.F, Ma, A.C, Yang, A.S. | | 登録日 | 2011-02-16 | | 公開日 | 2012-02-22 | | 最終更新日 | 2012-04-25 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Rationalization and design of the complementarity determining region sequences in an antibody-antigen recognition interface
Plos One, 7, 2012
|
|
4NT9
 | | Crystal structure of an L,D-carboxypeptidase DacB from Streptococcus pneumonia | | 分子名称: | ACETATE ION, GLYCEROL, Putative uncharacterized protein, ... | | 著者 | Yang, Y.H, Zhang, J, Jiang, Y.L, Zhou, C.Z, Chen, Y. | | 登録日 | 2013-12-02 | | 公開日 | 2014-11-12 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (1.705 Å) | | 主引用文献 | Crystal structure of an L,D-carboxypeptidase DacB from Streptococcus pneumonia
To be Published
|
|
6WXK
 | | PHF23 PHD Domain Apo | | 分子名称: | PHD finger protein 23, ZINC ION | | 著者 | Vann, K.R, Zhang, J, Zhang, Y, Kutateladze, T. | | 登録日 | 2020-05-11 | | 公開日 | 2020-07-15 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | Mechanistic insights into chromatin targeting by leukemic NUP98-PHF23 fusion.
Nat Commun, 11, 2020
|
|
5XEX
 | | Crystal structure of S.aureus PNPase catalytic domain | | 分子名称: | DI(HYDROXYETHYL)ETHER, GLYCEROL, PYROPHOSPHATE, ... | | 著者 | Wang, X, Zhang, X, Zang, J. | | 登録日 | 2017-04-06 | | 公開日 | 2017-10-18 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Enolase binds to RnpA in competition with PNPase in Staphylococcus aureus
FEBS Lett., 591, 2017
|
|
6WTT
 | | Crystals Structure of the SARS-CoV-2 (COVID-19) main protease with inhibitor GC-376 | | 分子名称: | (1R,2S)-2-({N-[(benzyloxy)carbonyl]-L-leucyl}amino)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propane-1-sulfonic acid, (1S,2S)-2-({N-[(benzyloxy)carbonyl]-L-leucyl}amino)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propane-1-sulfonic acid, 3C-like proteinase, ... | | 著者 | Sacco, M, Ma, C, Chen, Y, Wang, J. | | 登録日 | 2020-05-03 | | 公開日 | 2020-05-20 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | | 主引用文献 | Boceprevir, GC-376, and calpain inhibitors II, XII inhibit SARS-CoV-2 viral replication by targeting the viral main protease.
Cell Res., 30, 2020
|
|
7Y72
 | | SARS-CoV-2 spike glycoprotein trimer complexed with Fab fragment of anti-RBD antibody E7 (focused refinement on Fab-RBD interface) | | 分子名称: | Fab E7 heavy chain, Fab E7 light chain, Spike glycoprotein | | 著者 | Chia, W.N, Tan, C.W, Tan, A.W.K, Young, B, Starr, T.N, Lopez, E, Fibriansah, G, Barr, J, Cheng, S, Yeoh, A.Y.Y, Yap, W.C, Lim, B.L, Ng, T.S, Sia, W.R, Zhu, F, Chen, S, Zhang, J, Greaney, A.J, Chen, M, Au, G.G, Paradkar, P, Peiris, M, Chung, A.W, Bloom, J.D, Lye, D, Lok, S.M, Wang, L.F. | | 登録日 | 2022-06-21 | | 公開日 | 2023-08-02 | | 最終更新日 | 2023-08-09 | | 実験手法 | ELECTRON MICROSCOPY (4.03 Å) | | 主引用文献 | Potent pan huACE2-dependent sarbecovirus neutralizing monoclonal antibodies isolated from a BNT162b2-vaccinated SARS survivor.
Sci Adv, 9, 2023
|
|
