4GUU

Crystal structure of LSD2-NPAC with tranylcypromine

Summary for 4GUU

• Entry DOI: 10.2210/pdb4guu/pdb
• Descriptor: Lysine-specific histone demethylase 1B, Putative oxidoreductase GLYR1, [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl (2R,3S,4S)-5-[(3R,3aS,7aR)-10,11-dimethyl-1,4,6-trioxo-3-phenyl-2,3,5,6,7,7a-hexahydro-1H-benzo[g]pyrrolo[2,1-e]pteridin-8(4H)-yl]-2,3,4-trihydroxypentyl dihydrogen diphosphate, ... (5 entities in total)
• Functional Keywords: histone demethylase, oxidoreductase
• Biological source: Homo sapiens (human); More
• Cellular location: Nucleus (By similarity): Q8NB78; Nucleus: Q49A26
• Total number of polymer chains: 2
• Total formula weight: 101695.77

Authors

Chen, F.,Dong, Z.,Fang, J.,Yang, Y.,Li, Z.,Xu, Y.,Yang, H.,Wang, P.,Xu, Y. (deposition date: 2012-08-29, release date: 2013-01-16, Last modification date: 2023-11-08)

• Primary citation: Fang, R.,Chen, F.,Dong, Z.,Hu, D.,Barbera, A.J.,Clark, E.A.,Fang, J.,Yang, Y.,Mei, P.,Rutenberg, M.,Li, Z.,Zhang, Y.,Xu, Y.,Yang, H.,Wang, P.,Simon, M.D.,Zhou, Q.,Li, J.,Marynick, M.P.,Li, X.,Lu, H.,Kaiser, U.B.,Kingston, R.E.,Xu, Y.,Shi, Y.G.; LSD2/KDM1B and its cofactor NPAC/GLYR1 endow a structural and molecular model for regulation of H3K4 demethylation; Mol.Cell, 49:558-570, 2013; PubMed: 23260659; DOI: 10.1016/j.molcel.2012.11.019

Experimental method

X-RAY DIFFRACTION (2.302 Å)