4GUU

Crystal structure of LSD2-NPAC with tranylcypromine

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Lysine-specific histone demethylase 1B	polymer	776	87051.5	1	UniProt (Q8NB78) Pfam (PF07496) Pfam (PF04433) Pfam (PF01593)	Homo sapiens (human)	LSD2, Flavin-containing amine oxidase domain-containing protein 1, Lysine-specific histone demethylase 2
2	B (B)	Putative oxidoreductase GLYR1	polymer	124	13528.3	1	UniProt (Q49A26)	Homo sapiens (human)	NPAC, 3-hydroxyisobutyrate dehydrogenase-like protein, Cytokine-like nuclear factor N-PAC, Glyoxylate reductase 1 homolog, Nuclear protein NP60, Nuclear protein of 60 kDa
3	C (A)	[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl (2R,3S,4S)-5-[(3R,3aS,7aR)-10,11-dimethyl-1,4,6-trioxo-3-phenyl-2,3,5,6,7,7a-hexahydro-1H-benzo[g]pyrrolo[2,1-e]pteridin-8(4H)-yl]-2,3,4-trihydroxypentyl dihydrogen diphosphate	non-polymer		919.7	1	Chemie (FA9)
4	D, E, F (A)	ZINC ION	non-polymer		65.4	3	Chemie (ZN)
5	G, H (A, B)	water	water		18.0	219	Chemie (HOH)

Sequence modifications

A: 51 - 822 (UniProt: Q8NB78)

PDB	External Database	Details
Pro 47	-	expression tag
Leu 48	-	expression tag
Gly 49	-	expression tag
Ser 50	-	expression tag

B: 152 - 268 (UniProt: Q49A26)

PDB	External Database	Details
Pro 145	-	expression tag
Leu 146	-	expression tag
Gly 147	-	expression tag
Ser 148	-	expression tag
Pro 149	-	expression tag
Glu 150	-	expression tag
Phe 151	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	100579.8
Non-Polymers*	Number of molecules	4
	Total formula weight	1116.0
All*	Total formula weight	101695.8

*Water molecules are not included.