6WTT

Crystals Structure of the SARS-CoV-2 (COVID-19) main protease with inhibitor GC-376

Summary for 6WTT

• Entry DOI: 10.2210/pdb6wtt/pdb
• Descriptor: 3C-like proteinase, (1S,2S)-2-({N-[(benzyloxy)carbonyl]-L-leucyl}amino)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propane-1-sulfonic acid, DI(HYDROXYETHYL)ETHER, ... (8 entities in total)
• Functional Keywords: covid covid19 covid-19 sars sars cov2 cov ncov 19 coronavirus main protease 3cl mpro pro, viral protein, gc376, gc-376, peptidomimetic, protease, cysteine
• Biological source: Severe acute respiratory syndrome coronavirus 2 (2019-nCoV)
• Total number of polymer chains: 3
• Total formula weight: 105018.09

Authors

Sacco, M.,Ma, C.,Chen, Y.,Wang, J. (deposition date: 2020-05-03, release date: 2020-05-20, Last modification date: 2023-10-18)

• Primary citation: Ma, C.,Sacco, M.D.,Hurst, B.,Townsend, J.A.,Hu, Y.,Szeto, T.,Zhang, X.,Tarbet, B.,Marty, M.T.,Chen, Y.,Wang, J.; Boceprevir, GC-376, and calpain inhibitors II, XII inhibit SARS-CoV-2 viral replication by targeting the viral main protease.; Cell Res., 30:678-692, 2020; PubMed: 32541865; DOI: 10.1038/s41422-020-0356-z

Experimental method

X-RAY DIFFRACTION (2.15 Å)