6WTT
Crystals Structure of the SARS-CoV-2 (COVID-19) main protease with inhibitor GC-376
Summary for 6WTT
Entry DOI | 10.2210/pdb6wtt/pdb |
Descriptor | 3C-like proteinase, (1S,2S)-2-({N-[(benzyloxy)carbonyl]-L-leucyl}amino)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propane-1-sulfonic acid, DI(HYDROXYETHYL)ETHER, ... (8 entities in total) |
Functional Keywords | covid covid19 covid-19 sars sars cov2 cov ncov 19 coronavirus main protease 3cl mpro pro, viral protein, gc376, gc-376, peptidomimetic, protease, cysteine |
Biological source | Severe acute respiratory syndrome coronavirus 2 (2019-nCoV) |
Total number of polymer chains | 3 |
Total formula weight | 105018.09 |
Authors | |
Primary citation | Ma, C.,Sacco, M.D.,Hurst, B.,Townsend, J.A.,Hu, Y.,Szeto, T.,Zhang, X.,Tarbet, B.,Marty, M.T.,Chen, Y.,Wang, J. Boceprevir, GC-376, and calpain inhibitors II, XII inhibit SARS-CoV-2 viral replication by targeting the viral main protease. Cell Res., 30:678-692, 2020 Cited by PubMed: 32541865DOI: 10.1038/s41422-020-0356-z PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.15 Å) |
Structure validation
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