4NTJ

Structure of the human P2Y12 receptor in complex with an antithrombotic drug

Summary for 4NTJ

Entry DOI	10.2210/pdb4ntj/pdb
Descriptor	P2Y purinoceptor 12,Soluble cytochrome b562,P2Y purinoceptor 12, ethyl 6-{4-[(benzylsulfonyl)carbamoyl]piperidin-1-yl}-5-cyano-2-methylpyridine-3-carboxylate, CHOLESTEROL, ... (5 entities in total)
Functional Keywords	human p2y12 receptor, gpcr network, membrane protein, lipidic cubic phase, antithrombotic drug, gpcr, psi-biology, structural genomics, signaling protein, membrane
Biological source	Homo sapiens (Human) More
Cellular location	Cell membrane ; Multi-pass membrane protein : Q9H244
Total number of polymer chains	1
Total formula weight	55205.81
Authors	Zhang, K.,Zhang, J.,Gao, Z.-G.,Zhang, D.,Zhu, L.,Han, G.W.,Moss, S.M.,Paoletta, S.,Kiselev, E.,Lu, W.,Fenalti, G.,Zhang, W.,Muller, C.E.,Yang, H.,Jiang, H.,Cherezov, V.,Katritch, V.,Jacobson, K.A.,Stevens, R.C.,Wu, B.,Zhao, Q.,GPCR Network (GPCR) (deposition date: 2013-12-02, release date: 2014-03-26, Last modification date: 2023-11-08)
Primary citation	Zhang, K.,Zhang, J.,Gao, Z.-G.,Zhang, D.,Zhu, L.,Han, G.W.,Moss, S.M.,Paoletta, S.,Kiselev, E.,Lu, W.,Fenalti, G.,Zhang, W.,Muller, C.E.,Yang, H.,Jiang, H.,Cherezov, V.,Katritch, V.,Jacobson, K.A.,Stevens, R.C.,Wu, B.,Zhao, Q. Structure of the human P2Y12 receptor in complex with an antithrombotic drug Nature, 509:115-118, 2014 Cited by PubMed: 24670650 DOI: 10.1038/nature13083 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.62 Å)

Structure validation