4NTJ
Structure of the human P2Y12 receptor in complex with an antithrombotic drug
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | P2Y purinoceptor 12,Soluble cytochrome b562,P2Y purinoceptor 12 | polymer | 466 | 53248.9 | 1 | UniProt (Q9H244) UniProt (P0ABE7) Pfam (PF00001) Pfam (PF07361) In PDB | Homo sapiens (Human) | P2Y12,ADP-glucose receptor,ADPG-R,P2T(AC),P2Y(AC),P2Y(cyc),P2Y12 platelet ADP receptor,P2Y(ADP),SP1999 |
2 | A | ethyl 6-{4-[(benzylsulfonyl)carbamoyl]piperidin-1-yl}-5-cyano-2-methylpyridine-3-carboxylate | non-polymer | 470.5 | 1 | Chemie (AZJ) | |||
3 | A | CHOLESTEROL | non-polymer | 386.7 | 2 | Chemie (CLR) | |||
4 | A | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate | non-polymer | 356.5 | 2 | Chemie (OLC) | |||
5 | water | water | 18.0 | 12 | Chemie (HOH) |
Sequence modifications
A: 2 - 223 (UniProt: Q9H244)
A: 1001 - 1106 (UniProt: P0ABE7)
A: 224 - 342 (UniProt: Q9H244)
PDB | External Database | Details |
---|---|---|
Asp -8 | - | expression tag |
Tyr -7 | - | expression tag |
Lys -6 | - | expression tag |
Asp -5 | - | expression tag |
Asp -4 | - | expression tag |
Asp -3 | - | expression tag |
Asp -2 | - | expression tag |
Gly -1 | - | expression tag |
Ala 0 | - | expression tag |
Pro 1 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Trp 1007 | Met 29 | engineered mutation |
Ile 1102 | His 124 | engineered mutation |
Leu 1106 | Arg 128 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Asn 294 | Asp 294 | engineered mutation |
Gly 343 | - | expression tag |
Arg 344 | - | expression tag |
Pro 345 | - | expression tag |
Leu 346 | - | expression tag |
Glu 347 | - | expression tag |
Val 348 | - | expression tag |
Leu 349 | - | expression tag |
Phe 350 | - | expression tag |
Gln 351 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 53248.9 | |
Non-Polymers* | Number of molecules | 5 |
Total formula weight | 1956.9 | |
All* | Total formula weight | 55205.8 |