7Y72

SARS-CoV-2 spike glycoprotein trimer complexed with Fab fragment of anti-RBD antibody E7 (focused refinement on Fab-RBD interface)

Summary for 7Y72

Entry DOI	10.2210/pdb7y72/pdb
EMDB information	33651
Descriptor	Spike glycoprotein, Fab E7 light chain, Fab E7 heavy chain (3 entities in total)
Functional Keywords	viral protein
Biological source	Homo sapiens (human) More
Total number of polymer chains	4
Total formula weight	312980.14
Authors	Chia, W.N.,Tan, C.W.,Tan, A.W.K.,Young, B.,Starr, T.N.,Lopez, E.,Fibriansah, G.,Barr, J.,Cheng, S.,Yeoh, A.Y.Y.,Yap, W.C.,Lim, B.L.,Ng, T.S.,Sia, W.R.,Zhu, F.,Chen, S.,Zhang, J.,Greaney, A.J.,Chen, M.,Au, G.G.,Paradkar, P.,Peiris, M.,Chung, A.W.,Bloom, J.D.,Lye, D.,Lok, S.M.,Wang, L.F. (deposition date: 2022-06-21, release date: 2023-08-02, Last modification date: 2023-08-09)
Primary citation	Chia, W.N.,Tan, C.W.,Tan, A.W.K.,Young, B.,Starr, T.N.,Lopez, E.,Fibriansah, G.,Barr, J.,Cheng, S.,Yeoh, A.Y.,Yap, W.C.,Lim, B.L.,Ng, T.S.,Sia, W.R.,Zhu, F.,Chen, S.,Zhang, J.,Kwek, M.S.S.,Greaney, A.J.,Chen, M.,Au, G.G.,Paradkar, P.N.,Peiris, M.,Chung, A.W.,Bloom, J.D.,Lye, D.,Lok, S.,Wang, L.F. Potent pan huACE2-dependent sarbecovirus neutralizing monoclonal antibodies isolated from a BNT162b2-vaccinated SARS survivor. Sci Adv, 9:eade3470-eade3470, 2023 Cited by PubMed: 37494438 DOI: 10.1126/sciadv.ade3470 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (4.03 Å)

Structure validation