4APP
Crystal Structure of the Human p21-Activated Kinase 4 in Complex with (S)-N-(5-(3-benzyl-1-methylpiperazine-4-carbonyl)-6,6-dimethyl-1,4,5, 6-tetrahydropyrrolo(3,4-c)pyrazol-3-yl)-3-phenoxybenzamide
Summary for 4APP
Entry DOI | 10.2210/pdb4app/pdb |
Related | 2BVA 2CDZ 2J0I 2X4Z |
Descriptor | SERINE/THREONINE-PROTEIN KINASE PAK 4, N-[6,6-dimethyl-5-[(2S)-4-methyl-2-(phenylmethyl)piperazin-1-yl]carbonyl-2,4-dihydropyrrolo[3,4-c]pyrazol-3-yl]-3-phenoxy-benzamide, GLYCEROL, ... (4 entities in total) |
Functional Keywords | transferase, protein kinase |
Biological source | HOMO SAPIENS (HUMAN) |
Total number of polymer chains | 1 |
Total formula weight | 34081.61 |
Authors | Knighton, D.D.,Deng, Y.L.,Wang, C.,Guo, C.,McAlpine, I.,Zhang, J.,Kephart, S.,Johnson, M.C.,Li, H.,Bouzida, D.,Yang, A.,Dong, L.,Marakovits, J.,Tikhe, J.,Richardson, P.,Guo, L.C.,Kania, R.,Edwards, M.P.,Kraynov, E.,Christensen, J.,Piraino, J.,Lee, J.,Dagostino, E.,Del-Carmen, C.,Smeal, T.,Murray, B.W. (deposition date: 2012-04-04, release date: 2012-06-06, Last modification date: 2019-05-08) |
Primary citation | Guo, C.,Mcalpine, I.,Zhang, J.,Knighton, D.D.,Kephart, S.,Johnson, M.C.,Li, H.,Bouzida, D.,Yang, A.,Dong, L.,Marakovits, J.,Tikhe, J.,Richardson, P.,Guo, L.C.,Kania, R.,Edwards, M.P.,Kraynov, E.,Christensen, J.,Piraino, J.,Lee, J.,Dagostino, E.,Del-Carmen, C.,Deng, Y.L.,Smeal, T.,Murray, B.W. Discovery of Pyrroloaminopyrazoles as Novel Pak Inhibitors. J.Med.Chem., 55:4728-, 2012 Cited by PubMed: 22554206DOI: 10.1021/JM300204J PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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