2X4Z
Crystal Structure of the Human p21-Activated Kinase 4 in Complex with PF-03758309
Summary for 2X4Z
Entry DOI | 10.2210/pdb2x4z/pdb |
Related | 2BVA 2CDZ 2J0I |
Descriptor | SERINE/THREONINE-PROTEIN KINASE PAK 4, GLYCEROL, PF-3758309, ... (4 entities in total) |
Functional Keywords | transferase, nucleotide-binding atp-binding, phosphoprotein |
Biological source | HOMO SAPIENS (HUMAN) |
Total number of polymer chains | 1 |
Total formula weight | 34099.65 |
Authors | Knighton, D.R.,Deng, Y.,Murray, B.,Guo, C.,Piraino, J.,Westwick, J.,Zhang, C.,Lamerdin, J.,Dagostino, E.,Loi, C.-M.,Zager, M.,Kraynov, E.,Christensen, J.,Martinez, R.,Kephart, S.,Marakovits, J.,Karlicek, S.,Bergqvist, S.,Smeal, T. (deposition date: 2010-02-03, release date: 2010-05-19, Last modification date: 2019-01-23) |
Primary citation | Murray, B.,Guo, C.,Piraino, J.,Westwick, J.,Zhang, C.,Lamerdin, J.,Dagostino, E.,Knighton, D.R.,Loi, C.-M.,Zager, M.,Kraynov, E.,Popoff, I.,Christensen, J.,Martinez, R.,Kephart, S.,Marakovits, J.,Karlicek, S.,Bergqvist, S.,Smeal, T. Small-Molecule P21-Activated Kinase Inhibitor Pf- 3758309 is a Potent Inhibitor of Oncogenic Signaling and Tumor Growth. Proc.Natl.Acad.Sci.USA, 107:9446-, 2010 Cited by PubMed: 20439741DOI: 10.1073/PNAS.0911863107 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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