2X4Z
Crystal Structure of the Human p21-Activated Kinase 4 in Complex with PF-03758309
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | SERINE/THREONINE-PROTEIN KINASE PAK 4 | polymer | 296 | 33424.8 | 1 | UniProt (O96013) Pfam (PF00069) | HOMO SAPIENS (HUMAN) | P21-ACTIVATED KINASE 4, PAK-4 |
| 2 | B, C (A) | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
| 3 | D (A) | PF-3758309 | non-polymer | 490.6 | 1 | Chemie (7KC) | |||
| 4 | E (A) | water | water | 18.0 | 144 | Chemie (HOH) |
Sequence modifications
A: 296 - 591 (UniProt: O96013)
| PDB | External Database | Details |
|---|---|---|
| Gly 296 | Pro 296 | engineered mutation |
| Ser 297 | Gln 297 | engineered mutation |
| His 298 | Arg 298 | engineered mutation |
| Met 299 | Val 299 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 33424.8 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 674.8 | |
| All* | Total formula weight | 34099.7 |
