2X4Z

Crystal Structure of the Human p21-Activated Kinase 4 in Complex with PF-03758309

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004672	molecular_function	protein kinase activity
A	0005524	molecular_function	ATP binding
A	0006468	biological_process	protein phosphorylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL A 1591

Chain	Residue
A	SER331
A	ASP440
A	LYS442
A	7KC1593
A	HOH2079
A	HOH2141

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site_id	AC2
Number of Residues	9
Details	BINDING SITE FOR RESIDUE GOL A 1592

Chain	Residue
A	GLU366
A	ASP458
A	PHE459
A	GLY460
A	HOH2016
A	HOH2069
A	THR332
A	LYS350
A	MET352

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site_id	AC3
Number of Residues	20
Details	BINDING SITE FOR RESIDUE X4Z A 1593

Chain	Residue
A	ILE327
A	GLY328
A	GLY330
A	THR332
A	GLY333
A	VAL335
A	ALA348
A	LYS350
A	MET395
A	GLU396
A	PHE397
A	LEU398
A	GLU399
A	GLY401
A	ASP444
A	ASP458
A	GOL1591
A	HOH2142
A	HOH2143
A	HOH2144

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Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	25
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. IGEGSTGIVCiAtvrssgklv.........AVKK

Chain	Residue	Details
A	ILE327-LYS351

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159

Chain	Residue	Details
A	ASP440

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site_id	SWS_FT_FI2
Number of Residues	2
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000269|PubMed:26607847, ECO:0007744|PDB:4XBR, ECO:0007744|PDB:4XBU

Chain	Residue	Details
A	ILE327
A	LYS350

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site_id	SWS_FT_FI3
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269|PubMed:26607847, ECO:0007744|PDB:4XBR, ECO:0007744|PDB:4XBU

Chain	Residue	Details
A	GLU396
A	ASP458

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site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: Phosphoserine; by autocatalysis => ECO:0000269|Ref.32, ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:19369195, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163

Chain	Residue	Details
A	SEP474

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