2X4Z

Crystal Structure of the Human p21-Activated Kinase 4 in Complex with PF-03758309

Summary for 2X4Z

Entry DOI	10.2210/pdb2x4z/pdb
Related	2BVA 2CDZ 2J0I
Descriptor	SERINE/THREONINE-PROTEIN KINASE PAK 4, GLYCEROL, PF-3758309, ... (4 entities in total)
Functional Keywords	transferase, nucleotide-binding atp-binding, phosphoprotein
Biological source	HOMO SAPIENS (HUMAN)
Total number of polymer chains	1
Total formula weight	34099.65
Authors	Knighton, D.R.,Deng, Y.,Murray, B.,Guo, C.,Piraino, J.,Westwick, J.,Zhang, C.,Lamerdin, J.,Dagostino, E.,Loi, C.-M.,Zager, M.,Kraynov, E.,Christensen, J.,Martinez, R.,Kephart, S.,Marakovits, J.,Karlicek, S.,Bergqvist, S.,Smeal, T. (deposition date: 2010-02-03, release date: 2010-05-19, Last modification date: 2019-01-23)
Primary citation	Murray, B.,Guo, C.,Piraino, J.,Westwick, J.,Zhang, C.,Lamerdin, J.,Dagostino, E.,Knighton, D.R.,Loi, C.-M.,Zager, M.,Kraynov, E.,Popoff, I.,Christensen, J.,Martinez, R.,Kephart, S.,Marakovits, J.,Karlicek, S.,Bergqvist, S.,Smeal, T. Small-Molecule P21-Activated Kinase Inhibitor Pf- 3758309 is a Potent Inhibitor of Oncogenic Signaling and Tumor Growth. Proc.Natl.Acad.Sci.USA, 107:9446-, 2010 Cited by PubMed: 20439741 DOI: 10.1073/PNAS.0911863107 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation