4APP
Crystal Structure of the Human p21-Activated Kinase 4 in Complex with (S)-N-(5-(3-benzyl-1-methylpiperazine-4-carbonyl)-6,6-dimethyl-1,4,5, 6-tetrahydropyrrolo(3,4-c)pyrazol-3-yl)-3-phenoxybenzamide
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | SERINE/THREONINE-PROTEIN KINASE PAK 4 | polymer | 296 | 33424.8 | 1 | UniProt (O96013) Pfam (PF00069) In PDB | HOMO SAPIENS (HUMAN) | P21-ACTIVATED KINASE 4, PAK-4 |
| 2 | A | N-[6,6-dimethyl-5-[(2S)-4-methyl-2-(phenylmethyl)piperazin-1-yl]carbonyl-2,4-dihydropyrrolo[3,4-c]pyrazol-3-yl]-3-phenoxy-benzamide | non-polymer | 564.7 | 1 | Chemie (N53) | |||
| 3 | A | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 4 | water | water | 18.0 | 182 | Chemie (HOH) |
Sequence modifications
A: 300 - 591 (UniProt: O96013)
| PDB | External Database | Details |
|---|---|---|
| Gly 296 | - | expression tag |
| Ser 297 | - | expression tag |
| His 298 | - | expression tag |
| Met 299 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 33424.8 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 656.8 | |
| All* | Total formula weight | 34081.6 |
