4NIB
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4XST
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![BU of 4xst by Molmil](/molmil-images/mine/4xst) | Structure of the endoglycosidase-H treated L1-CR domains of the human insulin receptor in complex with residues 697-719 of the human insulin receptor (A-isoform) | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Insulin receptor, SULFATE ION, ... | 著者 | Menting, J.G, Lawrence, C.F, Kong, G.K.-W, Lawrence, M.C. | 登録日 | 2015-01-22 | 公開日 | 2015-06-10 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Structural Congruency of Ligand Binding to the Insulin and Insulin/Type 1 Insulin-like Growth Factor Hybrid Receptors. Structure, 23, 2015
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4OGA
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![BU of 4oga by Molmil](/molmil-images/mine/4oga) | |
4XSS
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![BU of 4xss by Molmil](/molmil-images/mine/4xss) | Insulin-like growth factor I in complex with site 1 of a hybrid insulin receptor / Type 1 insulin-like growth factor receptor | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Insulin receptor, ... | 著者 | Lawrence, C, Kong, G.K.-W, Menting, J.G, Lawrence, M.C. | 登録日 | 2015-01-22 | 公開日 | 2015-06-10 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Structural Congruency of Ligand Binding to the Insulin and Insulin/Type 1 Insulin-like Growth Factor Hybrid Receptors. Structure, 23, 2015
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6VET
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![BU of 6vet by Molmil](/molmil-images/mine/6vet) | Human insulin analog: [GluB10,HisA8,ArgA9,TyrB20]-DOI | 分子名称: | Insulin A chain, Insulin B chain | 著者 | Menting, J.G, Chou, D.H.-C, Lawrence, M.C, Xiong, X. | 登録日 | 2020-01-02 | 公開日 | 2020-06-03 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.46 Å) | 主引用文献 | A structurally minimized yet fully active insulin based on cone-snail venom insulin principles. Nat.Struct.Mol.Biol., 27, 2020
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6VEQ
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![BU of 6veq by Molmil](/molmil-images/mine/6veq) | Con-Ins G1 in complex with the human insulin microreceptor in turn in complex with Fv 83-7 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Con-Ins G1 B chain, Con-Ins G1a A chain, ... | 著者 | Menting, J.G, Chou, D.H.-C, Lawrence, M.C, Xiong, X. | 登録日 | 2020-01-02 | 公開日 | 2020-06-03 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (3.25 Å) | 主引用文献 | A structurally minimized yet fully active insulin based on cone-snail venom insulin principles. Nat.Struct.Mol.Biol., 27, 2020
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5T7R
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![BU of 5t7r by Molmil](/molmil-images/mine/5t7r) | A6-A11 trans-dicarba human insulin | 分子名称: | Insulin A chain, Insulin B chain | 著者 | Menting, J.G, Lawrence, M.C, Robinson, A.J, Forbes, B.E. | 登録日 | 2016-09-05 | 公開日 | 2017-12-06 | 最終更新日 | 2019-06-19 | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | 主引用文献 | Insulin in motion: The A6-A11 disulfide bond allosterically modulates structural transitions required for insulin activity. Sci Rep, 7, 2017
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7KD6
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6HN4
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![BU of 6hn4 by Molmil](/molmil-images/mine/6hn4) | Leucine-zippered human insulin receptor ectodomain with single bound insulin - "lower" membrane-proximal part | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Insulin receptor,Insulin receptor,General control protein GCN4 | 著者 | Weis, F, Menting, J.G, Margetts, M.B, Chan, S.J, Xu, Y, Tennagels, N, Wohlfart, P, Langer, T, Mueller, C.W, Dreyer, M.K, Lawrence, M.C. | 登録日 | 2018-09-14 | 公開日 | 2018-11-21 | 最終更新日 | 2022-03-30 | 実験手法 | ELECTRON MICROSCOPY (4.2 Å) | 主引用文献 | The signalling conformation of the insulin receptor ectodomain. Nat Commun, 9, 2018
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6HN5
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![BU of 6hn5 by Molmil](/molmil-images/mine/6hn5) | Leucine-zippered human insulin receptor ectodomain with single bound insulin - "upper" membrane-distal part | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Insulin, ... | 著者 | Weis, F, Menting, J.G, Margetts, M.B, Chan, S.J, Xu, Y, Tennagels, N, Wohlfart, P, Langer, T, Mueller, C.W, Dreyer, M.K, Lawrence, M.C. | 登録日 | 2018-09-14 | 公開日 | 2018-11-21 | 最終更新日 | 2022-03-30 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | The signalling conformation of the insulin receptor ectodomain. Nat Commun, 9, 2018
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6VEP
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![BU of 6vep by Molmil](/molmil-images/mine/6vep) | |
5KQV
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![BU of 5kqv by Molmil](/molmil-images/mine/5kqv) | Insulin receptor ectodomain construct comprising domains L1,CR,L2, FnIII-1 and alphaCT peptide in complex with bovine insulin and FAB 83-14 (REVISED STRUCTURE) | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Insulin, Insulin receptor,Insulin receptor, ... | 著者 | Lawrence, M.C, Smith, B.J, Croll, T.I. | 登録日 | 2016-07-06 | 公開日 | 2017-07-19 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (4.4 Å) | 主引用文献 | How insulin engages its primary binding site on the insulin receptor. Nature, 493, 2013
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5JYQ
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![BU of 5jyq by Molmil](/molmil-images/mine/5jyq) | Structure of Conus Geographus insulin G1 | 分子名称: | Insulin 1, Insulin 1b, SULFATE ION | 著者 | Lawrence, M.C, Menting, J, Norton, R.S, Safavi-Hemami, H. | 登録日 | 2016-05-15 | 公開日 | 2016-09-07 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | A minimized human insulin-receptor-binding motif revealed in a Conus geographus venom insulin. Nat.Struct.Mol.Biol., 23, 2016
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3W11
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![BU of 3w11 by Molmil](/molmil-images/mine/3w11) | |
3W13
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![BU of 3w13 by Molmil](/molmil-images/mine/3w13) | Insulin receptor ectodomain construct comprising domains L1-CR in complex with high-affinity insulin analogue [D-PRO-B26]-DTI-NH2, alphact peptide(693-719) and FAB 83-7 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Insulin A chain, Insulin B chain, ... | 著者 | Lawrence, M.C, Smith, B.J, Brzozowski, A.M. | 登録日 | 2012-11-06 | 公開日 | 2013-01-09 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (4.303 Å) | 主引用文献 | How insulin engages its primary binding site on the insulin receptor Nature, 493, 2013
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3W12
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![BU of 3w12 by Molmil](/molmil-images/mine/3w12) | Insulin receptor ectodomain construct comprising domains L1-CR in complex with high-affinity insulin analogue [D-PRO-B26]-DTI-NH2, alpha-CT peptide(704-719) and FAB 83-7 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Insulin A chain, Insulin B chain, ... | 著者 | Lawrence, M.C, Smith, B.J, Brzozowsk, A.M. | 登録日 | 2012-11-06 | 公開日 | 2013-01-09 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (4.301 Å) | 主引用文献 | How insulin engages its primary binding site on the insulin receptor Nature, 493, 2013
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6VER
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![BU of 6ver by Molmil](/molmil-images/mine/6ver) | Human insulin analog: [GluB10,TyrB20]-DOI | 分子名称: | Insulin A chain, Insulin B chain | 著者 | Menting, J.G, Chou, D.H.-C, Lawrence, M.C, Xiong, X. | 登録日 | 2020-01-02 | 公開日 | 2020-11-11 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.047 Å) | 主引用文献 | Mini-Ins: A minimal, bioactive insulin analog with alternative binding modes not published
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6VES
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![BU of 6ves by Molmil](/molmil-images/mine/6ves) | Human insulin analog: [GluB10,HisA8,ArgA9]-DOI | 分子名称: | Insulin A chain, Insulin B chain | 著者 | Menting, J.G, Chou, D.H.-C, Lawrence, M.C, Xiong, X. | 登録日 | 2020-01-02 | 公開日 | 2020-11-11 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Mini-Ins: A Minimal, Bioactive Insulin Analog with Alternative Binding Modes To Be Published
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2MLI
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![BU of 2mli by Molmil](/molmil-images/mine/2mli) | |
2MPI
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![BU of 2mpi by Molmil](/molmil-images/mine/2mpi) | Solution structure of B24G insulin | 分子名称: | insulin chain A, insulin chain B | 著者 | Yang, Y, Wickramasinghe, N.P, Hua, Q, Weiss, M.A. | 登録日 | 2014-05-19 | 公開日 | 2014-12-24 | 最終更新日 | 2023-06-14 | 実験手法 | SOLUTION NMR | 主引用文献 | Protective hinge in insulin opens to enable its receptor engagement. Proc.Natl.Acad.Sci.USA, 111, 2014
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7MQS
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![BU of 7mqs by Molmil](/molmil-images/mine/7mqs) | The insulin receptor ectodomain in complex with three venom hybrid insulin molecules - asymmetric conformation | 分子名称: | Insulin A chain, Insulin B chain, Isoform Short of Insulin receptor | 著者 | Blakely, A.D, Xiong, X, Kim, J.H, Menting, J, Schafer, I.B, Schubert, H.L, Agrawal, R, Gutmann, T, Delaine, C, Zhang, Y, Artik, G.O, Merriman, A, Eckert, D, Lawrence, M.C, Coskun, U, Fisher, S.J, Forbes, B.E, Safavi-Hemami, H, Hill, C.P, Chou, D.H.C. | 登録日 | 2021-05-06 | 公開日 | 2022-03-16 | 最終更新日 | 2023-03-29 | 実験手法 | ELECTRON MICROSCOPY (4.4 Å) | 主引用文献 | Symmetric and asymmetric receptor conformation continuum induced by a new insulin. Nat.Chem.Biol., 18, 2022
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7MQO
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![BU of 7mqo by Molmil](/molmil-images/mine/7mqo) | The insulin receptor ectodomain in complex with a venom hybrid insulin analog - "head" region | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Insulin A chain, ... | 著者 | Blakely, A.D, Xiong, X, Kim, J.H, Menting, J, Schafer, I.B, Schubert, H.L, Agrawal, R, Gutmann, T, Delaine, C, Zhang, Y, Artik, G.O, Merriman, A, Eckert, D, Lawrence, M.C, Coskun, U, Fisher, S.J, Forbes, B.E, Safavi-Hemami, H, Hill, C.P, Chou, D.H.C. | 登録日 | 2021-05-06 | 公開日 | 2022-03-16 | 最終更新日 | 2023-03-29 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Symmetric and asymmetric receptor conformation continuum induced by a new insulin. Nat.Chem.Biol., 18, 2022
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7MQR
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![BU of 7mqr by Molmil](/molmil-images/mine/7mqr) | The insulin receptor ectodomain in complex with four venom hybrid insulins - symmetric conformation | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Insulin A chain, Insulin B chain, ... | 著者 | Blakely, A.D, Xiong, X, Kim, J.H, Menting, J, Schafer, I.B, Schubert, H.L, Agrawal, R, Gutmann, T, Delaine, C, Zhang, Y, Artik, G.O, Merriman, A, Eckert, D, Lawrence, M.C, Coskun, U, Fisher, S.J, Forbes, B.E, Safavi-Hemami, H, Hill, C.P, Chou, D.H.C. | 登録日 | 2021-05-06 | 公開日 | 2022-03-16 | 最終更新日 | 2023-03-29 | 実験手法 | ELECTRON MICROSCOPY (4.1 Å) | 主引用文献 | Symmetric and asymmetric receptor conformation continuum induced by a new insulin. Nat.Chem.Biol., 18, 2022
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5J3H
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![BU of 5j3h by Molmil](/molmil-images/mine/5j3h) | Human insulin receptor domains L1-CR in complex with peptide S519C16 and 83-7 Fv | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Lawrence, M, Menting, J, Lawrence, C. | 登録日 | 2016-03-30 | 公開日 | 2016-06-15 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (3.27 Å) | 主引用文献 | Insulin Mimetic Peptide Disrupts the Primary Binding Site of the Insulin Receptor. J.Biol.Chem., 291, 2016
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4P65
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![BU of 4p65 by Molmil](/molmil-images/mine/4p65) | Crystal structure of an cyclohexylalanine substituted insulin analog. | 分子名称: | CHLORIDE ION, Insulin, PHENOL, ... | 著者 | Pandyarajan, V, Wan, Z, Weiss, M.A. | 登録日 | 2014-03-21 | 公開日 | 2014-10-22 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Aromatic Anchor at an Invariant Hormone-Receptor Interface: FUNCTION OF INSULIN RESIDUE B24 WITH APPLICATION TO PROTEIN DESIGN. J.Biol.Chem., 289, 2014
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