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6HN4

Leucine-zippered human insulin receptor ectodomain with single bound insulin - "lower" membrane-proximal part

Summary for 6HN4
Entry DOI10.2210/pdb6hn4/pdb
EMDB information0246
DescriptorInsulin receptor,Insulin receptor,General control protein GCN4, 2-acetamido-2-deoxy-beta-D-glucopyranose (2 entities in total)
Functional Keywordsinsulin, insulin receptor ectodomain, signal transdution, signaling protein
Biological sourceHomo sapiens (Human)
More
Total number of polymer chains2
Total formula weight214783.67
Authors
Weis, F.,Menting, J.G.,Margetts, M.B.,Chan, S.J.,Xu, Y.,Tennagels, N.,Wohlfart, P.,Langer, T.,Mueller, C.W.,Dreyer, M.K.,Lawrence, M.C. (deposition date: 2018-09-14, release date: 2018-11-21, Last modification date: 2022-03-30)
Primary citationWeis, F.,Menting, J.G.,Margetts, M.B.,Chan, S.J.,Xu, Y.,Tennagels, N.,Wohlfart, P.,Langer, T.,Muller, C.W.,Dreyer, M.K.,Lawrence, M.C.
The signalling conformation of the insulin receptor ectodomain.
Nat Commun, 9:4420-4420, 2018
Cited by
PubMed: 30356040
DOI: 10.1038/s41467-018-06826-6
PDB entries with the same primary citation
Experimental method
ELECTRON MICROSCOPY (4.2 Å)
Structure validation

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