6HN4

Leucine-zippered human insulin receptor ectodomain with single bound insulin - "lower" membrane-proximal part

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (E, F)	Insulin receptor,Insulin receptor,General control protein GCN4	polymer	930	106728.2	2	UniProt (P06213) UniProt (P03069) Pfam (PF01030) Pfam (PF00757) Pfam (PF00041) Pfam (PF17870) Pfam (PF07716)	Homo sapiens (Human)	IR,IR,Amino acid biosynthesis regulatory protein
2	C, D, E, F, G... (F)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	6	Chemie (NAG)

Sequence modifications

E, F: 1 - 734 (UniProt: P06213)

PDB	External Database	Details
His 144	Tyr 171	variant
Thr 421	Ile 448	variant
Lys 465	Gln 492	variant
Ala 731	Val 758	engineered mutation
Gly 732	Thr 759	engineered mutation
Asn 733	Val 760	engineered mutation
Asn 734	Ala 761	engineered mutation

E, F: 735 - 897 (UniProt: P06213)
E, F: 898 - 930 (UniProt: P03069)

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	213456.4
Non-Polymers*	Number of molecules	6
	Total formula weight	1327.2
All*	Total formula weight	214783.7

*Water molecules are not included.