6HN4

Leucine-zippered human insulin receptor ectodomain with single bound insulin - "lower" membrane-proximal part

Functional Information from GO Data

Chain	GOid	namespace	contents
E	0003700	molecular_function	DNA-binding transcription factor activity
E	0006355	biological_process	regulation of DNA-templated transcription
F	0003700	molecular_function	DNA-binding transcription factor activity
F	0006355	biological_process	regulation of DNA-templated transcription

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1460
Details	TOPO_DOM: Extracellular => ECO:0000305

Chain	Residue	Details
E	HIS1-ALA731
F	HIS1-ALA731

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site_id	SWS_FT_FI2
Number of Residues	2
Details	SITE: Insulin-binding => ECO:0000305

Chain	Residue	Details
E	PHE39
F	PHE39

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site_id	SWS_FT_FI3
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648

Chain	Residue	Details
E	SER373
E	SER380
F	SER373
F	SER380

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	MOD_RES: Phosphotyrosine => ECO:0007744|PubMed:18669648

Chain	Residue	Details
E	TYR374
F	TYR374

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16894147, ECO:0000269|PubMed:23302862, ECO:0000269|PubMed:2983222

Chain	Residue	Details
E	ASN16
F	ASN16

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site_id	SWS_FT_FI6
Number of Residues	6
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16894147, ECO:0000269|PubMed:23302862

Chain	Residue	Details
E	ASN25
E	ASN111
E	ASN255
F	ASN25
F	ASN111
F	ASN255

---

site_id	SWS_FT_FI7
Number of Residues	14
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
E	ASN78
F	ASN606
F	ASN624
F	ASN671
F	GLU736
F	THR887
E	ASN295
E	ASN606
E	ASN624
E	ASN671
E	GLU736
E	THR887
F	ASN78
F	ASN295

---

site_id	SWS_FT_FI8
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16894147, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:23302862

Chain	Residue	Details
E	ASN215
F	ASN215

---

site_id	SWS_FT_FI9
Number of Residues	4
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16894147

Chain	Residue	Details
E	ASN337
E	ASN397
F	ASN337
F	ASN397

---

site_id	SWS_FT_FI10
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16894147, ECO:0000269|PubMed:19349973

Chain	Residue	Details
E	ASN418
F	ASN418

---

site_id	SWS_FT_FI11
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:1472036, ECO:0000269|PubMed:19159218

Chain	Residue	Details
E	ASN514
F	ASN514

---

site_id	SWS_FT_FI12
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:2983222

Chain	Residue	Details
E	LYS742
F	LYS742

---

site_id	SWS_FT_FI13
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19349973

Chain	Residue	Details
E	GLY874
F	GLY874

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Catalytic Information from CSA

site_id	MCSA1
Number of Residues
Details	M-CSA 246

Chain

Residue

Details

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site_id	MCSA2
Number of Residues
Details	M-CSA 246

Chain

Residue

Details

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