Loading
PDBj
English日本語简体中文繁體中文한국어
✖
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help
Search by PDB author
6HN5
DownloadVisualize
BU of 6hn5 by Molmil
Leucine-zippered human insulin receptor ectodomain with single bound insulin - "upper" membrane-distal part
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Insulin, ...
Authors:Weis, F, Menting, J.G, Margetts, M.B, Chan, S.J, Xu, Y, Tennagels, N, Wohlfart, P, Langer, T, Mueller, C.W, Dreyer, M.K, Lawrence, M.C.
Deposit date:2018-09-14
Release date:2018-11-21
Last modified:2022-03-30
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:The signalling conformation of the insulin receptor ectodomain.
Nat Commun, 9, 2018
6HN4
DownloadVisualize
BU of 6hn4 by Molmil
Leucine-zippered human insulin receptor ectodomain with single bound insulin - "lower" membrane-proximal part
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Insulin receptor,Insulin receptor,General control protein GCN4
Authors:Weis, F, Menting, J.G, Margetts, M.B, Chan, S.J, Xu, Y, Tennagels, N, Wohlfart, P, Langer, T, Mueller, C.W, Dreyer, M.K, Lawrence, M.C.
Deposit date:2018-09-14
Release date:2018-11-21
Last modified:2022-03-30
Method:ELECTRON MICROSCOPY (4.2 Å)
Cite:The signalling conformation of the insulin receptor ectodomain.
Nat Commun, 9, 2018
4ZXB
DownloadVisualize
BU of 4zxb by Molmil
Structure of the human insulin receptor ectodomain, IRDeltabeta construct, in complex with four Fab molecules
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Croll, T, Smith, B.J, Margetts, M.B, Whittaker, J, Weiss, M.A, Ward, C.W, Lawrence, M.C.
Deposit date:2015-05-20
Release date:2016-02-24
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Higher-Resolution Structure of the Human Insulin Receptor Ectodomain: Multi-Modal Inclusion of the Insert Domain.
Structure, 24, 2016
5KQV
DownloadVisualize
BU of 5kqv by Molmil
Insulin receptor ectodomain construct comprising domains L1,CR,L2, FnIII-1 and alphaCT peptide in complex with bovine insulin and FAB 83-14 (REVISED STRUCTURE)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Insulin, Insulin receptor,Insulin receptor, ...
Authors:Lawrence, M.C, Smith, B.J, Croll, T.I.
Deposit date:2016-07-06
Release date:2017-07-19
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (4.4 Å)
Cite:How insulin engages its primary binding site on the insulin receptor.
Nature, 493, 2013
7S0Q
DownloadVisualize
BU of 7s0q by Molmil
Head region of a complex of IGF-I with the ectodomain of a hybrid insulin receptor / type 1 insulin-like growth factor receptor
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Insulin receptor, ...
Authors:Xu, Y, Lawrence, M.C.
Deposit date:2021-08-30
Release date:2022-07-06
Last modified:2022-08-17
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:How insulin-like growth factor I binds to a hybrid insulin receptor type 1 insulin-like growth factor receptor.
Structure, 30, 2022
5J3H
DownloadVisualize
BU of 5j3h by Molmil
Human insulin receptor domains L1-CR in complex with peptide S519C16 and 83-7 Fv
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Lawrence, M, Menting, J, Lawrence, C.
Deposit date:2016-03-30
Release date:2016-06-15
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (3.27 Å)
Cite:Insulin Mimetic Peptide Disrupts the Primary Binding Site of the Insulin Receptor.
J.Biol.Chem., 291, 2016
8DI2
DownloadVisualize
BU of 8di2 by Molmil
Site 2 insulin receptor binding peptide IM459N21
Descriptor: Site 2 binding peptide IM459N21
Authors:Lawrence, M.C, Hu, H, Martinez, F.J, Espinosa, J.F.
Deposit date:2022-06-28
Release date:2022-11-09
Method:SOLUTION NMR
Cite:Activation of the human insulin receptor by non-insulin-related peptides.
Nat Commun, 13, 2022
7S8V
DownloadVisualize
BU of 7s8v by Molmil
Leg region of a complex of IGF-I with the ectodomain of a hybrid insulin receptor / type 1 insulin-like growth factor receptor
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Insulin receptor, ...
Authors:Xu, Y, Lawrence, M.C.
Deposit date:2021-09-20
Release date:2022-07-06
Last modified:2022-08-17
Method:ELECTRON MICROSCOPY (3.73 Å)
Cite:How insulin-like growth factor I binds to a hybrid insulin receptor type 1 insulin-like growth factor receptor.
Structure, 30, 2022
7U6D
DownloadVisualize
BU of 7u6d by Molmil
Head region of insulin receptor ectodomain (A-isoform) bound to the non-insulin agonist IM459
Descriptor: IM459, Isoform Short of Insulin receptor
Authors:Kirk, N.S, Lawrence, M.C.
Deposit date:2022-03-03
Release date:2022-10-05
Method:ELECTRON MICROSCOPY (5.03 Å)
Cite:Activation of the human insulin receptor by non-insulin-related peptides
Nat Commun, 13, 2022
7U6E
DownloadVisualize
BU of 7u6e by Molmil
Head region of insulin receptor ectodomain (A-isoform) bound to the non-insulin agonist IM462
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, IM462, ...
Authors:Kirk, N.S, Lawrence, M.C.
Deposit date:2022-03-03
Release date:2022-10-05
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Activation of the human insulin receptor by non-insulin-related peptides
Nat Commun, 13, 2022
4XST
DownloadVisualize
BU of 4xst by Molmil
Structure of the endoglycosidase-H treated L1-CR domains of the human insulin receptor in complex with residues 697-719 of the human insulin receptor (A-isoform)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Insulin receptor, SULFATE ION, ...
Authors:Menting, J.G, Lawrence, C.F, Kong, G.K.-W, Lawrence, M.C.
Deposit date:2015-01-22
Release date:2015-06-10
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structural Congruency of Ligand Binding to the Insulin and Insulin/Type 1 Insulin-like Growth Factor Hybrid Receptors.
Structure, 23, 2015
4XSS
DownloadVisualize
BU of 4xss by Molmil
Insulin-like growth factor I in complex with site 1 of a hybrid insulin receptor / Type 1 insulin-like growth factor receptor
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Insulin receptor, ...
Authors:Lawrence, C, Kong, G.K.-W, Menting, J.G, Lawrence, M.C.
Deposit date:2015-01-22
Release date:2015-06-10
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structural Congruency of Ligand Binding to the Insulin and Insulin/Type 1 Insulin-like Growth Factor Hybrid Receptors.
Structure, 23, 2015
5U8Q
DownloadVisualize
BU of 5u8q by Molmil
Structure of the ectodomain of the human Type 1 insulin-like growth factor receptor in complex with IGF-I
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, D-MALATE, ...
Authors:Lawrence, M, Xu, Y.
Deposit date:2016-12-14
Release date:2018-02-28
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (3.2710402 Å)
Cite:How ligand binds to the type 1 insulin-like growth factor receptor.
Nat Commun, 9, 2018
5U8R
DownloadVisualize
BU of 5u8r by Molmil
Structure of the ectodomain of the human Type 1 insulin-like growth factor receptor
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, D-MALATE, ...
Authors:Lawrence, M, Xu, Y.
Deposit date:2016-12-14
Release date:2018-02-28
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (3.00001621 Å)
Cite:How ligand binds to the type 1 insulin-like growth factor receptor.
Nat Commun, 9, 2018
6VWI
DownloadVisualize
BU of 6vwi by Molmil
Head region of the closed conformation of the human type 1 insulin-like growth factor receptor ectodomain in complex with human insulin-like growth factor II.
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Insulin-like growth factor II, Leucine-zippered human type 1 insulin-like growth factor receptor ectodomain
Authors:Xu, Y, Kirk, N.S, Lawrence, M.C, Croll, T.I.
Deposit date:2020-02-19
Release date:2020-05-13
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:How IGF-II Binds to the Human Type 1 Insulin-like Growth Factor Receptor.
Structure, 28, 2020
6VWH
DownloadVisualize
BU of 6vwh by Molmil
Leg region of the open conformation of the human type 1 insulin-like growth factor receptor ectodomain in complex with human insulin-like growth factor II.
Descriptor: Leucine-zippered human type 1 insulin-like growth factor receptor ectodomain
Authors:Xu, Y, Kirk, N.S, Lawrence, M.C, Croll, T.I.
Deposit date:2020-02-19
Release date:2020-05-13
Last modified:2020-07-22
Method:ELECTRON MICROSCOPY (4.26 Å)
Cite:How IGF-II Binds to the Human Type 1 Insulin-like Growth Factor Receptor.
Structure, 28, 2020
6VWG
DownloadVisualize
BU of 6vwg by Molmil
Head region of the open conformation of the human type 1 insulin-like growth factor receptor ectodomain in complex with human insulin-like growth factor II.
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Insulin-like growth factor II, Leucine-zippered human type 1 insulin-like growth factor receptor ectodomain
Authors:Xu, Y, Kirk, N.S, Lawrence, M.C, Croll, T.I.
Deposit date:2020-02-19
Release date:2020-05-13
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (3.21 Å)
Cite:How IGF-II Binds to the Human Type 1 Insulin-like Growth Factor Receptor.
Structure, 28, 2020
6VWJ
DownloadVisualize
BU of 6vwj by Molmil
Leg region of the closed conformation of the human type 1 insulin-like growth factor receptor ectodomain in complex with human insulin-like growth factor II
Descriptor: Leucine-zippered human type 1 insulin-like growth factor receptor ectodomain
Authors:Xu, Y, Kirk, N.S, Lawrence, M.C, Croll, T.I.
Deposit date:2020-02-19
Release date:2020-05-13
Last modified:2020-07-22
Method:ELECTRON MICROSCOPY (4.21 Å)
Cite:How IGF-II Binds to the Human Type 1 Insulin-like Growth Factor Receptor.
Structure, 28, 2020
3W11
DownloadVisualize
BU of 3w11 by Molmil
Insulin receptor ectodomain construct comprising domains L1-CR in complex with human insulin, Alpha-CT peptide(704-719) and FAB 83-7
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Insulin A chain, Insulin B chain, ...
Authors:Lawrence, M.C, Smith, B.J.
Deposit date:2012-11-06
Release date:2013-01-09
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (3.9 Å)
Cite:How insulin engages its primary binding site on the insulin receptor
Nature, 493, 2013
3W13
DownloadVisualize
BU of 3w13 by Molmil
Insulin receptor ectodomain construct comprising domains L1-CR in complex with high-affinity insulin analogue [D-PRO-B26]-DTI-NH2, alphact peptide(693-719) and FAB 83-7
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Insulin A chain, Insulin B chain, ...
Authors:Lawrence, M.C, Smith, B.J, Brzozowski, A.M.
Deposit date:2012-11-06
Release date:2013-01-09
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (4.303 Å)
Cite:How insulin engages its primary binding site on the insulin receptor
Nature, 493, 2013
3W12
DownloadVisualize
BU of 3w12 by Molmil
Insulin receptor ectodomain construct comprising domains L1-CR in complex with high-affinity insulin analogue [D-PRO-B26]-DTI-NH2, alpha-CT peptide(704-719) and FAB 83-7
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Insulin A chain, Insulin B chain, ...
Authors:Lawrence, M.C, Smith, B.J, Brzozowsk, A.M.
Deposit date:2012-11-06
Release date:2013-01-09
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (4.301 Å)
Cite:How insulin engages its primary binding site on the insulin receptor
Nature, 493, 2013

218853

PDB entries from 2024-04-24

PDB statisticsPDBj update infoContact PDBjnumon