7U6E

Head region of insulin receptor ectodomain (A-isoform) bound to the non-insulin agonist IM462

Summary for 7U6E

• Entry DOI: 10.2210/pdb7u6e/pdb
• EMDB information: 26363 26364
• Descriptor: Insulin A chain, Insulin B chain, Isoform Short of Insulin receptor, ... (6 entities in total)
• Functional Keywords: insulin receptor, insulin-mimic peptide, insulin receptor agonist, hormone-signaling protein-agonist complex, hormone/signaling protein/agonist
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 6
• Total formula weight: 226315.45

Authors

Kirk, N.S.,Lawrence, M.C. (deposition date: 2022-03-03, release date: 2022-10-05)

• Primary citation: Kirk, N.S.,Chen, Q.,Wu, Y.G.,Asante, A.L.,Hu, H.,Espinosa, J.F.,Martinez-Olid, F.,Margetts, M.B.,Mohammed, F.A.,Kiselyov, V.V.,Barrett, D.G.,Lawrence, M.C.; Activation of the human insulin receptor by non-insulin-related peptides; Nat Commun, 13:5695-, 2022; PubMed: 36171189; DOI: 10.1038/s41467-022-33315-8

Experimental method

ELECTRON MICROSCOPY (3 Å)