7U6E
Head region of insulin receptor ectodomain (A-isoform) bound to the non-insulin agonist IM462
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Insulin A chain | polymer | 21 | 2383.7 | 1 | UniProt (P01308) In PDB | Homo sapiens (human) | |
2 | B | Insulin B chain | polymer | 30 | 3434.0 | 1 | UniProt (P01308) Pfam (PF00049) In PDB | Homo sapiens (human) | |
3 | E, F | Isoform Short of Insulin receptor | polymer | 930 | 106728.2 | 2 | UniProt (P06213-2) Pfam (PF01030) Pfam (PF00757) Pfam (PF00041) Pfam (PF17870) UniProt (by SIFTS) (P06213) In PDB | Homo sapiens (human) | IR |
4 | G, H | IM462 | polymer | 23 | 2644.9 | 2 | synthetic construct | ||
5 | C | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 1 | In PDB GlyTouCan (G42666HT) | |||
6 | E, F | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 6 | Chemie (NAG) |
Sequence modifications
E, F: 1 - 897 (UniProt: P06213-2)
PDB | External Database | Details |
---|---|---|
His 144 | Tyr 171 | conflict |
Thr 421 | Ile 448 | conflict |
Lys 465 | Gln 492 | conflict |
- | Val 758 | deletion |
- | Thr 759 | deletion |
- | Val 760 | deletion |
- | Ala 761 | deletion |
- | Val 762 | deletion |
- | Pro 763 | deletion |
- | Thr 764 | deletion |
- | Val 765 | deletion |
- | Ala 766 | deletion |
- | Ala 767 | deletion |
- | Phe 768 | deletion |
- | Pro 769 | deletion |
- | Asn 770 | deletion |
- | Thr 771 | deletion |
- | Ser 772 | deletion |
- | Ser 773 | deletion |
- | Thr 774 | deletion |
- | Ser 775 | deletion |
- | Val 776 | deletion |
Ala 731 | Pro 777 | conflict |
Gly 732 | Thr 778 | conflict |
Asn 733 | Ser 779 | conflict |
Asn 734 | Pro 780 | conflict |
Arg 898 | - | expression tag |
Met 899 | - | expression tag |
Lys 900 | - | expression tag |
Gln 901 | - | expression tag |
Leu 902 | - | expression tag |
Glu 903 | - | expression tag |
Asp 904 | - | expression tag |
Lys 905 | - | expression tag |
Val 906 | - | expression tag |
Glu 907 | - | expression tag |
Glu 908 | - | expression tag |
Leu 909 | - | expression tag |
Leu 910 | - | expression tag |
Ser 911 | - | expression tag |
Lys 912 | - | expression tag |
Asn 913 | - | expression tag |
Tyr 914 | - | expression tag |
His 915 | - | expression tag |
Leu 916 | - | expression tag |
Glu 917 | - | expression tag |
Asn 918 | - | expression tag |
Glu 919 | - | expression tag |
Val 920 | - | expression tag |
Ala 921 | - | expression tag |
Arg 922 | - | expression tag |
Leu 923 | - | expression tag |
Lys 924 | - | expression tag |
Lys 925 | - | expression tag |
Leu 926 | - | expression tag |
Val 927 | - | expression tag |
Gly 928 | - | expression tag |
Glu 929 | - | expression tag |
Arg 930 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 6 |
Total formula weight | 224563.8 | |
Branched | Number of molecules | 1 |
Total formula weight | 424.4 | |
Non-Polymers* | Number of molecules | 6 |
Total formula weight | 1327.2 | |
All* | Total formula weight | 226315.4 |