7U6E
Head region of insulin receptor ectodomain (A-isoform) bound to the non-insulin agonist IM462
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Insulin A chain | polymer | 21 | 2383.7 | 1 | UniProt (P01308) | Homo sapiens (human) | |
| 2 | B (B) | Insulin B chain | polymer | 30 | 3434.0 | 1 | UniProt (P01308) Pfam (PF00049) | Homo sapiens (human) | |
| 3 | C, D (E, F) | Isoform Short of Insulin receptor | polymer | 930 | 106728.2 | 2 | UniProt (P06213-2) Pfam (PF01030) Pfam (PF00757) Pfam (PF00041) Pfam (PF17870) UniProt (by SIFTS) (P06213) | Homo sapiens (human) | IR |
| 4 | E, F (G, H) | IM462 | polymer | 23 | 2644.9 | 2 | synthetic construct | ||
| 5 | G (C) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 1 | In PDB GlyTouCan (G42666HT) | |||
| 6 | H, I, J, K, L... (E, F) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 6 | Chemie (NAG) |
Sequence modifications
E, F: 1 - 897 (UniProt: P06213-2)
| PDB | External Database | Details |
|---|---|---|
| His 144 | Tyr 171 | conflict |
| Thr 421 | Ile 448 | conflict |
| Lys 465 | Gln 492 | conflict |
| - | Val 758 | deletion |
| - | Thr 759 | deletion |
| - | Val 760 | deletion |
| - | Ala 761 | deletion |
| - | Val 762 | deletion |
| - | Pro 763 | deletion |
| - | Thr 764 | deletion |
| - | Val 765 | deletion |
| - | Ala 766 | deletion |
| - | Ala 767 | deletion |
| - | Phe 768 | deletion |
| - | Pro 769 | deletion |
| - | Asn 770 | deletion |
| - | Thr 771 | deletion |
| - | Ser 772 | deletion |
| - | Ser 773 | deletion |
| - | Thr 774 | deletion |
| - | Ser 775 | deletion |
| - | Val 776 | deletion |
| Ala 731 | Pro 777 | conflict |
| Gly 732 | Thr 778 | conflict |
| Asn 733 | Ser 779 | conflict |
| Asn 734 | Pro 780 | conflict |
| Arg 898 | - | expression tag |
| Met 899 | - | expression tag |
| Lys 900 | - | expression tag |
| Gln 901 | - | expression tag |
| Leu 902 | - | expression tag |
| Glu 903 | - | expression tag |
| Asp 904 | - | expression tag |
| Lys 905 | - | expression tag |
| Val 906 | - | expression tag |
| Glu 907 | - | expression tag |
| Glu 908 | - | expression tag |
| Leu 909 | - | expression tag |
| Leu 910 | - | expression tag |
| Ser 911 | - | expression tag |
| Lys 912 | - | expression tag |
| Asn 913 | - | expression tag |
| Tyr 914 | - | expression tag |
| His 915 | - | expression tag |
| Leu 916 | - | expression tag |
| Glu 917 | - | expression tag |
| Asn 918 | - | expression tag |
| Glu 919 | - | expression tag |
| Val 920 | - | expression tag |
| Ala 921 | - | expression tag |
| Arg 922 | - | expression tag |
| Leu 923 | - | expression tag |
| Lys 924 | - | expression tag |
| Lys 925 | - | expression tag |
| Leu 926 | - | expression tag |
| Val 927 | - | expression tag |
| Gly 928 | - | expression tag |
| Glu 929 | - | expression tag |
| Arg 930 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 224563.8 | |
| Branched | Number of molecules | 1 |
| Total formula weight | 424.4 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 1327.2 | |
| All* | Total formula weight | 226315.4 |
