6VWI

Head region of the closed conformation of the human type 1 insulin-like growth factor receptor ectodomain in complex with human insulin-like growth factor II.

Summary for 6VWI

Entry DOI	10.2210/pdb6vwi/pdb
EMDB information	21415 21416 21417 21418
Descriptor	Leucine-zippered human type 1 insulin-like growth factor receptor ectodomain, Insulin-like growth factor II, 2-acetamido-2-deoxy-beta-D-glucopyranose (3 entities in total)
Functional Keywords	type 1 insulin-like growth factor receptor, insulin-like growth factor ii, ectodomain receptor, tyrosine kinase, signaling protein
Biological source	Homo sapiens (Human) More
Total number of polymer chains	3
Total formula weight	226243.79
Authors	Xu, Y.,Kirk, N.S.,Lawrence, M.C.,Croll, T.I. (deposition date: 2020-02-19, release date: 2020-05-13, Last modification date: 2020-07-29)
Primary citation	Xu, Y.,Kirk, N.S.,Venugopal, H.,Margetts, M.B.,Croll, T.I.,Sandow, J.J.,Webb, A.I.,Delaine, C.A.,Forbes, B.E.,Lawrence, M.C. How IGF-II Binds to the Human Type 1 Insulin-like Growth Factor Receptor. Structure, 28:786-798.e6, 2020 Cited by PubMed: 32459985 DOI: 10.1016/j.str.2020.05.002 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.7 Å)

Structure validation