6VWI

Head region of the closed conformation of the human type 1 insulin-like growth factor receptor ectodomain in complex with human insulin-like growth factor II.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Leucine-zippered human type 1 insulin-like growth factor receptor ectodomain	polymer	952	108937.2	2	UniProt (P08069) UniProt (P03069) Pfam (PF01030) Pfam (PF00757) Pfam (PF07716) In PDB	Homo sapiens (Human)	Insulin-like growth factor I receptor,IGF-I receptor,Amino acid biosynthesis regulatory protein
2	I	Insulin-like growth factor II	polymer	67	7484.5	1	UniProt (P01344) Pfam (PF00049) In PDB	Homo sapiens (Human)	IGF-II,Somatomedin-A,T3M-11-derived growth factor
3	A, B	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	4	Chemie (NAG)

Sequence modifications

A, B: 1 - 905 (UniProt: P08069)
A, B: 906 - 938 (UniProt: P03069)

PDB	External Database	Details
Ser 939	-	expression tag
Ser 940	-	expression tag
Ser 941	-	expression tag
Glu 942	-	expression tag
Gln 943	-	expression tag
Lys 944	-	expression tag
Leu 945	-	expression tag
Ile 946	-	expression tag
Ser 947	-	expression tag
Glu 948	-	expression tag
Glu 949	-	expression tag
Asp 950	-	expression tag
Leu 951	-	expression tag
Asn 952	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	225359.0
Non-Polymers*	Number of molecules	4
	Total formula weight	884.8
All*	Total formula weight	226243.8

*Water molecules are not included.