6VWI

Head region of the closed conformation of the human type 1 insulin-like growth factor receptor ectodomain in complex with human insulin-like growth factor II.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003700	molecular_function	DNA-binding transcription factor activity
A	0006355	biological_process	regulation of DNA-templated transcription
B	0003700	molecular_function	DNA-binding transcription factor activity
B	0006355	biological_process	regulation of DNA-templated transcription
I	0005179	molecular_function	hormone activity
I	0005576	cellular_component	extracellular region
I	0005615	cellular_component	extracellular space
I	0008083	molecular_function	growth factor activity

Functional Information from PROSITE/UniProt

site_id	PS00262
Number of Residues	15
Details	INSULIN Insulin family signature. CCFRsCDlalLetyC

Chain	Residue	Details
I	CYS46-CYS60

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	SITE: Important for interaction with integrin => ECO:0000269|PubMed:28873464

Chain	Residue	Details
I	ARG24
I	ARG34
I	ARG37
I	ARG38

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site_id	SWS_FT_FI2
Number of Residues	8
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:9690478

Chain	Residue	Details
A	ASN21
A	ASN105
A	ASN214
A	ASN284
B	ASN21
B	ASN105
B	ASN214
B	ASN284

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site_id	SWS_FT_FI3
Number of Residues	24
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	ASN72
A	ASN734
A	ASN870
A	ASN883
B	ASN72
B	ASN387
B	ASN408
B	ASN504
B	ASN577
B	ASN592
B	ASN610
A	ASN387
B	ASN717
B	ASN726
B	ASN734
B	ASN870
B	ASN883
A	ASN408
A	ASN504
A	ASN577
A	ASN592
A	ASN610
A	ASN717
A	ASN726

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