6VWI

Head region of the closed conformation of the human type 1 insulin-like growth factor receptor ectodomain in complex with human insulin-like growth factor II.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003700	molecular_function	DNA-binding transcription factor activity
A	0006355	biological_process	regulation of DNA-templated transcription
B	0003700	molecular_function	DNA-binding transcription factor activity
B	0006355	biological_process	regulation of DNA-templated transcription
I	0005179	molecular_function	hormone activity
I	0005576	cellular_component	extracellular region
I	0005615	cellular_component	extracellular space
I	0008083	molecular_function	growth factor activity

Functional Information from PROSITE/UniProt

site_id	PS00262
Number of Residues	15
Details	INSULIN Insulin family signature. CCFRsCDlalLetyC

Chain	Residue	Details
I	CYS46-CYS60

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"9690478","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	7
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	20
Details	Region: {"description":"A"}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	3
Details	Site: {"description":"Important for interaction with integrin","evidences":[{"source":"PubMed","id":"28873464","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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