6HN5

Leucine-zippered human insulin receptor ectodomain with single bound insulin - "upper" membrane-distal part

Summary for 6HN5

Entry DOI	10.2210/pdb6hn5/pdb
EMDB information	0247
Descriptor	Insulin, Insulin receptor,General control protein GCN4, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
Functional Keywords	insulin, insulin receptor ectodomain, signal transduction, signaling protein
Biological source	Homo sapiens (Human) More
Total number of polymer chains	4
Total formula weight	221689.35
Authors	Weis, F.,Menting, J.G.,Margetts, M.B.,Chan, S.J.,Xu, Y.,Tennagels, N.,Wohlfart, P.,Langer, T.,Mueller, C.W.,Dreyer, M.K.,Lawrence, M.C. (deposition date: 2018-09-14, release date: 2018-11-21, Last modification date: 2022-03-30)
Primary citation	Weis, F.,Menting, J.G.,Margetts, M.B.,Chan, S.J.,Xu, Y.,Tennagels, N.,Wohlfart, P.,Langer, T.,Muller, C.W.,Dreyer, M.K.,Lawrence, M.C. The signalling conformation of the insulin receptor ectodomain. Nat Commun, 9:4420-4420, 2018 Cited by PubMed: 30356040 DOI: 10.1038/s41467-018-06826-6 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.2 Å)

Structure validation