6HN5
Leucine-zippered human insulin receptor ectodomain with single bound insulin - "upper" membrane-distal part
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Insulin | polymer | 21 | 2383.7 | 1 | UniProt (P01308) | Homo sapiens | |
| 2 | B (B) | Insulin | polymer | 30 | 3434.0 | 1 | UniProt (P01308) Pfam (PF00049) | Homo sapiens | |
| 3 | C, D (E, F) | Insulin receptor,General control protein GCN4 | polymer | 930 | 106728.2 | 2 | UniProt (P06213) UniProt (P03069) Pfam (PF01030) Pfam (PF00757) Pfam (PF00041) Pfam (PF17870) Pfam (PF07716) | Homo sapiens (Human) | IR,IR,Amino acid biosynthesis regulatory protein |
| 4 | E (C) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 1 | In PDB GlyTouCan (G42666HT) | |||
| 5 | F, G, H, I, J... (E, F) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 9 | Chemie (NAG) |
Sequence modifications
E, F: 1 - 734 (UniProt: P06213)
E, F: 735 - 897 (UniProt: P06213)
E, F: 898 - 930 (UniProt: P03069)
| PDB | External Database | Details |
|---|---|---|
| His 144 | Tyr 171 | variant |
| Thr 421 | Ile 448 | variant |
| Lys 465 | Gln 492 | variant |
| Ala 731 | Val 758 | engineered mutation |
| Gly 732 | Thr 759 | engineered mutation |
| Asn 733 | Val 760 | engineered mutation |
| Asn 734 | Ala 761 | engineered mutation |
E, F: 898 - 930 (UniProt: P03069)
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 219274.1 | |
| Branched | Number of molecules | 1 |
| Total formula weight | 424.4 | |
| Non-Polymers* | Number of molecules | 9 |
| Total formula weight | 1990.9 | |
| All* | Total formula weight | 221689.3 |
