Insulin receptor ectodomain construct comprising domains L1-CR in complex with human insulin, Alpha-CT peptide(704-719) and FAB 83-7

Summary for 3W11

Related2DTG 3LOH 3W12 3W13 3W14
DescriptorInsulin A chain, Insulin B chain, monoclonal antibody fab 83-7 fragment - heavy chain, ... (9 entities in total)
Functional Keywordscell surface receptor/immune system, insulin receptor, ir ectodomain, ct peptide, insulin, hormone-hormone receptor-immune system complex, hormone/hormone receptor/immune system
Biological sourceHomo sapiens (human)
Cellular locationSecreted P01308 P01308
Cell membrane; Single-pass type I membrane protein 3W11 3W11
Total number of polymer chains6
Total molecular weight70903.34
Lawrence, M.C.,Smith, B.J. (deposition date: 2012-11-06, release date: 2013-01-09, Last modification date: 2013-09-04)
Primary citation
Menting, J.G.,Whittaker, J.,Margetts, M.B.,Whittaker, L.J.,Kong, G.K.-W.,Smith, B.J.,Watson, C.J.,Zakova, L.,Kletvikova, E.,Jiracek, J.,Chan, S.J.,Steiner, D.F.,Dodson, G.G.,Brzozowski, A.M.,Weiss, M.A.,Ward, C.W.,Lawrence, M.C.
How insulin engages its primary binding site on the insulin receptor
Nature, 493:241-245, 2013
PubMed: 23302862 (PDB entries with the same primary citation)
DOI: 10.1038/nature11781
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.326142.2%2.7%12.5%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report