3W11

Insulin receptor ectodomain construct comprising domains L1-CR in complex with human insulin, Alpha-CT peptide(704-719) and FAB 83-7

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Insulin A chain	polymer	21	2383.7	1	UniProt (P01308)	Homo sapiens (human)
2	B (B)	Insulin B chain	polymer	30	3434.0	1	UniProt (P01308) Pfam (PF00049)	Homo sapiens (human)
3	C (C)	monoclonal antibody fab 83-7 fragment - heavy chain	polymer	118	12886.4	1		Mus musculus (mouse)
4	D (D)	monoclonal antibody fab 83-7 fragment - light chain	polymer	114	12684.3	1		Mus musculus (mouse)
5	E (E)	Insulin receptor domains L1-CR	polymer	310	35503.9	1	UniProt (P06213) Pfam (PF01030) Pfam (PF00757)	Homo sapiens (human)	Insulin receptor L1-CR; IR310.T, Insulin receptor subunit alpha
6	F (F)	Insulin receptor alpha-CT peptide	polymer	16	1922.1	1	UniProt (P06213)	HOMO SAPIENS	Insulin receptor subunit alpha
7	G (G)	alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		748.7	1	In PDB GlyTouCan (G81315DD)
8	H (H)	beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		586.5	1	In PDB GlyTouCan (G15407YE)
9	I, J, K (E)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	3	Chemie (NAG)

Sequence modifications

E: 1 - 310 (UniProt: P06213)

PDB	External Database	Details
His 144	Tyr 171	SEE REMARK 999

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	68814.4
Branched	Number of molecules	2
	Total formula weight	1335.2
Non-Polymers*	Number of molecules	3
	Total formula weight	663.6
All*	Total formula weight	70813.3

*Water molecules are not included.