3W12
Insulin receptor ectodomain construct comprising domains L1-CR in complex with high-affinity insulin analogue [D-PRO-B26]-DTI-NH2, alpha-CT peptide(704-719) and FAB 83-7
Summary for 3W12
Entry DOI | 10.2210/pdb3w12/pdb |
Related | 2DTG 2WRW 3LOH 3W11 3W13 3W14 |
Descriptor | Insulin receptor domains L1-CR, monoclonal antibody fab 83-7 fragment - heavy chain, monoclonal antibody fab 83-7 fragment - light chain, ... (9 entities in total) |
Functional Keywords | cell surface receptor/immune system, insulin receptor, ir ectodomain, ct peptide, insulin, hormone receptor-hormone-immune system complex, hormone receptor/hormone/immune system |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 6 |
Total formula weight | 69922.35 |
Authors | Lawrence, M.C.,Smith, B.J.,Brzozowsk, A.M. (deposition date: 2012-11-06, release date: 2013-01-09, Last modification date: 2023-11-08) |
Primary citation | Menting, J.G.,Whittaker, J.,Margetts, M.B.,Whittaker, L.J.,Kong, G.K.-W.,Smith, B.J.,Watson, C.J.,Zakova, L.,Kletvikova, E.,Jiracek, J.,Chan, S.J.,Steiner, D.F.,Dodson, G.G.,Brzozowski, A.M.,Weiss, M.A.,Ward, C.W.,Lawrence, M.C. How insulin engages its primary binding site on the insulin receptor Nature, 493:241-245, 2013 Cited by PubMed: 23302862DOI: 10.1038/nature11781 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (4.301 Å) |
Structure validation
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