3W12

Insulin receptor ectodomain construct comprising domains L1-CR in complex with high-affinity insulin analogue [D-PRO-B26]-DTI-NH2, alpha-CT peptide(704-719) and FAB 83-7

Summary for 3W12

• Entry DOI: 10.2210/pdb3w12/pdb
• Related: 2DTG 2WRW 3LOH 3W11 3W13 3W14
• Descriptor: Insulin receptor domains L1-CR, monoclonal antibody fab 83-7 fragment - heavy chain, monoclonal antibody fab 83-7 fragment - light chain, ... (9 entities in total)
• Functional Keywords: cell surface receptor/immune system, insulin receptor, ir ectodomain, ct peptide, insulin, hormone receptor-hormone-immune system complex, hormone receptor/hormone/immune system
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 6
• Total formula weight: 69922.35

Authors

Lawrence, M.C.,Smith, B.J.,Brzozowsk, A.M. (deposition date: 2012-11-06, release date: 2013-01-09, Last modification date: 2023-11-08)

• Primary citation: Menting, J.G.,Whittaker, J.,Margetts, M.B.,Whittaker, L.J.,Kong, G.K.-W.,Smith, B.J.,Watson, C.J.,Zakova, L.,Kletvikova, E.,Jiracek, J.,Chan, S.J.,Steiner, D.F.,Dodson, G.G.,Brzozowski, A.M.,Weiss, M.A.,Ward, C.W.,Lawrence, M.C.; How insulin engages its primary binding site on the insulin receptor; Nature, 493:241-245, 2013; PubMed: 23302862; DOI: 10.1038/nature11781

Experimental method

X-RAY DIFFRACTION (4.301 Å)