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4ZXB

Structure of the human insulin receptor ectodomain, IRDeltabeta construct, in complex with four Fab molecules

Replaces:  2DTGReplaces:  3LOH
Summary for 4ZXB
Entry DOI10.2210/pdb4zxb/pdb
DescriptorFab 83-7 heavy chain, 2-acetamido-2-deoxy-beta-D-glucopyranose, Fab 83-7 light chain, ... (10 entities in total)
Functional Keywordsreceptor tyrosine kinase extracellular domain antibody fragments, hormone receptor-immune system complex, hormone receptor/immune system
Biological sourceMus musculus
More
Total number of polymer chains5
Total formula weight202011.27
Authors
Croll, T.,Smith, B.J.,Margetts, M.B.,Whittaker, J.,Weiss, M.A.,Ward, C.W.,Lawrence, M.C. (deposition date: 2015-05-20, release date: 2016-02-24, Last modification date: 2020-07-29)
Primary citationCroll, T.I.,Smith, B.J.,Margetts, M.B.,Whittaker, J.,Weiss, M.A.,Ward, C.W.,Lawrence, M.C.
Higher-Resolution Structure of the Human Insulin Receptor Ectodomain: Multi-Modal Inclusion of the Insert Domain.
Structure, 24:469-476, 2016
Cited by
PubMed: 26853939
DOI: 10.1016/j.str.2015.12.014
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (3.3 Å)
Structure validation

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