4ZXB
Structure of the human insulin receptor ectodomain, IRDeltabeta construct, in complex with four Fab molecules
Replaces: 2DTGReplaces: 3LOHEntity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Fab 83-7 heavy chain | polymer | 219 | 23414.3 | 1 | UniProt (U5LP42) Pfam (PF07686) Pfam (PF07654) | Mus musculus | |
| 2 | B (B) | Fab 83-7 light chain | polymer | 219 | 24385.1 | 1 | UniProt (P01837) Pfam (PF07654) | Mus musculus | |
| 3 | C (C) | Fab 83-14 heavy chain | polymer | 220 | 23622.7 | 1 | UniProt (P01865) Pfam (PF07654) | Mus musculus | |
| 4 | D (D) | Fab 83-14 light chain | polymer | 214 | 23514.8 | 1 | UniProt (A2P1G9) Pfam (PF07686) Pfam (PF07654) | Mus musculus | |
| 5 | E (E) | Insulin receptor | polymer | 894 | 102279.9 | 1 | UniProt (P06213) Pfam (PF00041) Pfam (PF17870) Pfam (PF01030) Pfam (PF00757) | Homo sapiens | |
| 6 | F, H, K (F, H, K) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 570.5 | 3 | In PDB GlyTouCan (G21290RB) | |||
| 7 | G (G) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 1 | In PDB GlyTouCan (G15407YE) | |||
| 8 | I (I) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1098.0 | 1 | In PDB GlyTouCan (G39203UC) | |||
| 9 | J, L (J, L) | alpha-L-fucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 367.3 | 2 | In PDB GlyTouCan (G86851RC) | |||
| 10 | M, N, O (E) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 3 | Chemie (NAG) |
Sequence modifications
A: 1 - 137 (PDB: 4ZXB)
A: 138 - 219 (UniProt: U5LP42)
B: 1 - 113 (PDB: 4ZXB)
B: 114 - 219 (UniProt: P01837)
C: 1 - 120 (PDB: 4ZXB)
C: 121 - 220 (UniProt: P01865)
D: 1 - 94 (PDB: 4ZXB)
D: 95 - 214 (UniProt: A2P1G9)
E: 1 - 917 (UniProt: P06213)
A: 138 - 219 (UniProt: U5LP42)
B: 1 - 113 (PDB: 4ZXB)
B: 114 - 219 (UniProt: P01837)
C: 1 - 120 (PDB: 4ZXB)
C: 121 - 220 (UniProt: P01865)
D: 1 - 94 (PDB: 4ZXB)
D: 95 - 214 (UniProt: A2P1G9)
E: 1 - 917 (UniProt: P06213)
| PDB | External Database | Details |
|---|---|---|
| His 144 | Tyr 171 | engineered mutation |
| - | Arg 747 | deletion |
| - | Lys 748 | deletion |
| - | Arg 749 | deletion |
| - | Arg 750 | deletion |
| - | Val 758 | deletion |
| - | Thr 759 | deletion |
| - | Val 760 | deletion |
| - | Ala 761 | deletion |
| - | Val 762 | deletion |
| - | Pro 763 | deletion |
| - | Thr 764 | deletion |
| - | Val 765 | deletion |
| - | Ala 766 | deletion |
| - | Ala 767 | deletion |
| - | Phe 768 | deletion |
| - | Pro 769 | deletion |
| - | Asn 770 | deletion |
| - | Thr 771 | deletion |
| - | Ser 772 | deletion |
| - | Ser 773 | deletion |
| - | Thr 774 | deletion |
| - | Ser 775 | deletion |
| - | Val 776 | deletion |
| Ala 750 | Pro 777 | engineered mutation |
| Gly 751 | Thr 778 | engineered mutation |
| Asn 752 | Ser 779 | engineered mutation |
| Asn 753 | Pro 780 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 197216.8 | |
| Branched | Number of molecules | 7 |
| Total formula weight | 4130.9 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 663.6 | |
| All* | Total formula weight | 202011.3 |
