4ZXB
Structure of the human insulin receptor ectodomain, IRDeltabeta construct, in complex with four Fab molecules
Replaces: 2DTGReplaces: 3LOHSummary for 4ZXB
Entry DOI | 10.2210/pdb4zxb/pdb |
Descriptor | Fab 83-7 heavy chain, 2-acetamido-2-deoxy-beta-D-glucopyranose, Fab 83-7 light chain, ... (10 entities in total) |
Functional Keywords | receptor tyrosine kinase extracellular domain antibody fragments, hormone receptor-immune system complex, hormone receptor/immune system |
Biological source | Mus musculus More |
Total number of polymer chains | 5 |
Total formula weight | 202011.27 |
Authors | Croll, T.,Smith, B.J.,Margetts, M.B.,Whittaker, J.,Weiss, M.A.,Ward, C.W.,Lawrence, M.C. (deposition date: 2015-05-20, release date: 2016-02-24, Last modification date: 2020-07-29) |
Primary citation | Croll, T.I.,Smith, B.J.,Margetts, M.B.,Whittaker, J.,Weiss, M.A.,Ward, C.W.,Lawrence, M.C. Higher-Resolution Structure of the Human Insulin Receptor Ectodomain: Multi-Modal Inclusion of the Insert Domain. Structure, 24:469-476, 2016 Cited by PubMed: 26853939DOI: 10.1016/j.str.2015.12.014 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.3 Å) |
Structure validation
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