3W13

Insulin receptor ectodomain construct comprising domains L1-CR in complex with high-affinity insulin analogue [D-PRO-B26]-DTI-NH2, alphact peptide(693-719) and FAB 83-7

Summary for 3W13

Related2DTG 3LOH 2WRW 3W11 3W12 3W14
DescriptorInsulin receptor domains L1-CR, monoclonal antibody fab 83-7 fragment - heavy chain, monoclonal antibody fab 83-7 fragment - light chain, ... (9 entities in total)
Functional Keywordscell surface receptor/immune system, insulin receptor, ir ectodomain, ct peptide, insulin analogue, hormone receptor-hormone-immune system complex, hormone receptor/hormone/immune system
Biological sourceHomo sapiens (human)
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Cellular locationCell membrane; Single-pass type I membrane protein P06213 3W13
Secreted P06213 3W13
Total number of polymer chains6
Total molecular weight70878.36
Authors
Lawrence, M.C.,Smith, B.J.,Brzozowski, A.M. (deposition date: 2012-11-06, release date: 2013-01-09, Last modification date: 2013-09-04)
Primary citation
Menting, J.G.,Whittaker, J.,Margetts, M.B.,Whittaker, L.J.,Kong, G.K.-W.,Smith, B.J.,Watson, C.J.,Zakova, L.,Kletvikova, E.,Jiracek, J.,Chan, S.J.,Steiner, D.F.,Dodson, G.G.,Brzozowski, A.M.,Weiss, M.A.,Ward, C.W.,Lawrence, M.C.
How insulin engages its primary binding site on the insulin receptor
Nature, 493:241-245, 2013
PubMed: 23302862 (PDB entries with the same primary citation)
DOI: 10.1038/nature11781
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (4.303 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.313142.0%4.5%0.9%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution