3W13
Insulin receptor ectodomain construct comprising domains L1-CR in complex with high-affinity insulin analogue [D-PRO-B26]-DTI-NH2, alphact peptide(693-719) and FAB 83-7
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | E | Insulin receptor domains L1-CR | polymer | 310 | 35503.9 | 1 | UniProt (P06213) Pfam (PF01030) Pfam (PF00757) In PDB | Homo sapiens (human) | insulin receptor L1-CR (IR310.T), Insulin receptor subunit alpha |
2 | C | monoclonal antibody fab 83-7 fragment - heavy chain | polymer | 116 | 12712.2 | 1 | Mus musculus (mouse) | ||
3 | D | monoclonal antibody fab 83-7 fragment - light chain | polymer | 114 | 12684.3 | 1 | Mus musculus (mouse) | ||
4 | A | Insulin A chain | polymer | 21 | 2383.7 | 1 | UniProt (P01308) In PDB | HOMO SAPIENS | |
5 | B | Insulin B chain | polymer | 26 | 2938.4 | 1 | UniProt (P01308) In PDB | HOMO SAPIENS | |
6 | F | Insulin receptor alphact peptide | polymer | 23 | 2788.1 | 1 | UniProt (P06213) In PDB | HOMO SAPIENS | Insulin receptor subunit alpha |
7 | G | alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 748.7 | 1 | In PDB GlyTouCan (G81315DD) | |||
8 | H | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 1 | In PDB GlyTouCan (G15407YE) | |||
9 | E | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 2 | Chemie (NAG) |
Sequence modifications
E: 1 - 310 (UniProt: P06213)
B: 1 - 26 (UniProt: P01308)
PDB | External Database | Details |
---|---|---|
His 144 | Tyr 171 | SEE REMARK 999 |
PDB | External Database | Details |
---|---|---|
Pr9 26 | Tyr 50 | SEE REMARK 999 |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 6 |
Total formula weight | 69010.6 | |
Branched | Number of molecules | 2 |
Total formula weight | 1335.2 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 442.4 | |
All* | Total formula weight | 70788.3 |