6VWH

Leg region of the open conformation of the human type 1 insulin-like growth factor receptor ectodomain in complex with human insulin-like growth factor II.

Summary for 6VWH

• Entry DOI: 10.2210/pdb6vwh/pdb
• EMDB information: 21416
• Descriptor: Leucine-zippered human type 1 insulin-like growth factor receptor ectodomain (1 entity in total)
• Functional Keywords: type 1 insulin-like growth factor receptor, insulin-like growth factor ii, ectodomain receptor, tyrosine kinase, signaling protein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 217874.48

Authors

Xu, Y.,Kirk, N.S.,Lawrence, M.C.,Croll, T.I. (deposition date: 2020-02-19, release date: 2020-05-13, Last modification date: 2020-07-22)

• Primary citation: Xu, Y.,Kirk, N.S.,Venugopal, H.,Margetts, M.B.,Croll, T.I.,Sandow, J.J.,Webb, A.I.,Delaine, C.A.,Forbes, B.E.,Lawrence, M.C.; How IGF-II Binds to the Human Type 1 Insulin-like Growth Factor Receptor.; Structure, 28:786-798.e6, 2020; PubMed: 32459985; DOI: 10.1016/j.str.2020.05.002

Experimental method

ELECTRON MICROSCOPY (4.26 Å)