7MQR

The insulin receptor ectodomain in complex with four venom hybrid insulins - symmetric conformation

Summary for 7MQR

Entry DOI	10.2210/pdb7mqr/pdb
EMDB information	23950
Descriptor	Insulin A chain, Insulin B chain, Isoform Short of Insulin receptor, ... (4 entities in total)
Functional Keywords	insulin, receptor, venom, cone snail, hormone, toxin
Biological source	Homo sapiens (Human) More
Total number of polymer chains	10
Total formula weight	234785.78
Authors	Blakely, A.D.,Xiong, X.,Kim, J.H.,Menting, J.,Schafer, I.B.,Schubert, H.L.,Agrawal, R.,Gutmann, T.,Delaine, C.,Zhang, Y.,Artik, G.O.,Merriman, A.,Eckert, D.,Lawrence, M.C.,Coskun, U.,Fisher, S.J.,Forbes, B.E.,Safavi-Hemami, H.,Hill, C.P.,Chou, D.H.C. (deposition date: 2021-05-06, release date: 2022-03-16, Last modification date: 2023-03-29)
Primary citation	Xiong, X.,Blakely, A.,Kim, J.H.,Menting, J.G.,Schafer, I.B.,Schubert, H.L.,Agrawal, R.,Gutmann, T.,Delaine, C.,Zhang, Y.W.,Artik, G.O.,Merriman, A.,Eckert, D.,Lawrence, M.C.,Coskun, U.,Fisher, S.J.,Forbes, B.E.,Safavi-Hemami, H.,Hill, C.P.,Chou, D.H. Symmetric and asymmetric receptor conformation continuum induced by a new insulin. Nat.Chem.Biol., 18:511-519, 2022 Cited by PubMed: 35289328 DOI: 10.1038/s41589-022-00981-0 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (4.1 Å)

Structure validation