7MQR
The insulin receptor ectodomain in complex with four venom hybrid insulins - symmetric conformation
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, D, F, H (A, C, G, I) | Insulin A chain | polymer | 24 | 2736.1 | 4 | UniProt (P01308) | Homo sapiens | |
| 2 | B, E, G, I (B, D, H, J) | Insulin B chain | polymer | 22 | 2538.0 | 4 | UniProt (P01308) | Homo sapiens | |
| 3 | C, J (E, F) | Isoform Short of Insulin receptor | polymer | 916 | 104632.7 | 2 | UniProt (P06213) Pfam (PF01030) Pfam (PF00757) Pfam (PF00041) Pfam (PF17870) | Homo sapiens (Human) | IR |
| 4 | AA, BA, CA, DA, K... (F, E) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 20 | Chemie (NAG) |
Sequence modifications
A, C, G, I: 1 - 21 (UniProt: P01308)
B, D, H, J: 1 - 22 (UniProt: P01308)
| PDB | External Database | Details |
|---|---|---|
| His 21 | Asn 110 | engineered mutation |
| Ser 22 | - | insertion |
| Leu 23 | - | insertion |
| Gln 24 | - | insertion |
| PDB | External Database | Details |
|---|---|---|
| Glu 10 | His 34 | engineered mutation |
| Leu 20 | Gly 44 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 10 |
| Total formula weight | 230361.6 | |
| Non-Polymers* | Number of molecules | 20 |
| Total formula weight | 4424.2 | |
| All* | Total formula weight | 234785.8 |
