7MQR

The insulin receptor ectodomain in complex with four venom hybrid insulins - symmetric conformation

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C, G, I	Insulin A chain	polymer	24	2736.1	4	UniProt (P01308) In PDB	Homo sapiens
2	B, D, H, J	Insulin B chain	polymer	22	2538.0	4	UniProt (P01308) In PDB	Homo sapiens
3	E, F	Isoform Short of Insulin receptor	polymer	916	104632.7	2	UniProt (P06213) Pfam (PF01030) Pfam (PF00757) Pfam (PF00041) Pfam (PF17870) In PDB	Homo sapiens (Human)	IR
4	F, E	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	20	Chemie (NAG)

Sequence modifications

A, C, G, I: 1 - 21 (UniProt: P01308)

PDB	External Database	Details
His 21	Asn 110	engineered mutation
Ser 22	-	insertion
Leu 23	-	insertion
Gln 24	-	insertion

B, D, H, J: 1 - 22 (UniProt: P01308)

PDB	External Database	Details
Glu 10	His 34	engineered mutation
Leu 20	Gly 44	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	10
	Total formula weight	230361.6
Non-Polymers*	Number of molecules	20
	Total formula weight	4424.2
All*	Total formula weight	234785.8

*Water molecules are not included.