6VEP

Human insulin in complex with the human insulin microreceptor in turn in complex with Fv 83-7

Summary for 6VEP

• Entry DOI: 10.2210/pdb6vep/pdb
• Descriptor: Insulin chain A, alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (14 entities in total)
• Functional Keywords: hormone, hormone receptor-hormone-immune system complex, hormone receptor/hormone/immune system
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 24
• Total formula weight: 299392.02

Authors

Lawrence, M.C.,Menting, J.G.T. (deposition date: 2020-01-02, release date: 2020-06-03, Last modification date: 2023-10-11)

• Primary citation: Xiong, X.,Menting, J.G.,Disotuar, M.M.,Smith, N.A.,Delaine, C.A.,Ghabash, G.,Agrawal, R.,Wang, X.,He, X.,Fisher, S.J.,MacRaild, C.A.,Norton, R.S.,Gajewiak, J.,Forbes, B.E.,Smith, B.J.,Safavi-Hemami, H.,Olivera, B.,Lawrence, M.C.,Chou, D.H.; A structurally minimized yet fully active insulin based on cone-snail venom insulin principles.; Nat.Struct.Mol.Biol., 27:615-624, 2020; PubMed: 32483339; DOI: 10.1038/s41594-020-0430-8

Experimental method

X-RAY DIFFRACTION (2.9 Å)