6VEP
Human insulin in complex with the human insulin microreceptor in turn in complex with Fv 83-7
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, G, M, S (A, G, M, S) | Insulin chain A | polymer | 21 | 2383.7 | 4 | UniProt (P01308) | Homo sapiens (Human) | |
| 2 | B, H, N, T (B, H, N, T) | Insulin B chain | polymer | 30 | 3434.0 | 4 | UniProt (P01308) Pfam (PF00049) | Homo sapiens (Human) | |
| 3 | C, I, O, U (C, I, O, U) | Fv 83-7 heavy chain | polymer | 138 | 15058.7 | 4 | Mus musculus (Mouse) | ||
| 4 | D, J, P, V (D, J, P, V) | Fv 83-7 light chain | polymer | 121 | 13367.9 | 4 | Mus musculus (Mouse) | ||
| 5 | E, K, Q, W (E, K, Q, W) | Insulin receptor subunit alpha | polymer | 317 | 36231.8 | 4 | UniProt (P06213) Pfam (PF01030) Pfam (PF00757) | Homo sapiens (Human) | IR |
| 6 | F, L, R, X (F, L, R, X) | Insulin receptor subunit beta | polymer | 16 | 1922.1 | 4 | UniProt (P06213) | Homo sapiens | IR |
| 7 | CA, Y (c, Y) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 570.5 | 2 | In PDB GlyTouCan (G21290RB) | |||
| 8 | AA, FA, GA, JA, Z (a, f, g, j, Z) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 732.7 | 5 | In PDB GlyTouCan (G32152BH) | |||
| 9 | BA, HA (b, h) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 2 | In PDB GlyTouCan (G42666HT) | |||
| 10 | DA (d) | alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 894.8 | 1 | In PDB GlyTouCan (G00395TQ) | |||
| 11 | EA (e) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 1 | In PDB GlyTouCan (G15407YE) | |||
| 12 | IA (i) | alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 894.8 | 1 | In PDB GlyTouCan (G42466VF) | |||
| 13 | KA, LA, MA, NA, OA... (E, K, Q, W) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 8 | Chemie (NAG) | |||
| 14 | AB, BB, CB, SA, TA... (R, V, W, C, E...) | water | water | 18.0 | 18 | Chemie (HOH) |
Sequence modifications
E, K, Q, W: 1 - 310 (UniProt: P06213)
F, L, R, X: 704 - 719 (UniProt: P06213)
| PDB | External Database | Details |
|---|---|---|
| His 144 | Tyr 171 | conflict |
| Ser 311 | - | expression tag |
| Ser 312 | - | expression tag |
| Ser 313 | - | expression tag |
| Leu 314 | - | expression tag |
| Val 315 | - | expression tag |
| Pro 316 | - | expression tag |
| Arg 317 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Pro 718 | Lys 745 | conflict |
| Ser 719 | Thr 746 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 24 |
| Total formula weight | 289592.9 | |
| Branched | Number of molecules | 12 |
| Total formula weight | 8029.5 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 1769.7 | |
| All* | Total formula weight | 299392.0 |
