6VEP

Human insulin in complex with the human insulin microreceptor in turn in complex with Fv 83-7

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005179	molecular_function	hormone activity
A	0005576	cellular_component	extracellular region
B	0005179	molecular_function	hormone activity
B	0005576	cellular_component	extracellular region
G	0005179	molecular_function	hormone activity
G	0005576	cellular_component	extracellular region
H	0005179	molecular_function	hormone activity
H	0005576	cellular_component	extracellular region
M	0005179	molecular_function	hormone activity
M	0005576	cellular_component	extracellular region
N	0005179	molecular_function	hormone activity
N	0005576	cellular_component	extracellular region
S	0005179	molecular_function	hormone activity
S	0005576	cellular_component	extracellular region
T	0005179	molecular_function	hormone activity
T	0005576	cellular_component	extracellular region

Functional Information from PROSITE/UniProt

site_id	PS00262
Number of Residues	15
Details	INSULIN Insulin family signature. CCTSiCSlyqLenyC

Chain	Residue	Details
A	CYS6-CYS20

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	SITE: Insulin-binding => ECO:0000305

Chain	Residue	Details
E	PHE39
K	PHE39
Q	PHE39
W	PHE39

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16894147, ECO:0000269|PubMed:23302862, ECO:0000269|PubMed:2983222

Chain	Residue	Details
E	ASN16
K	ASN16
Q	ASN16
W	ASN16

---

site_id	SWS_FT_FI3
Number of Residues	12
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16894147, ECO:0000269|PubMed:23302862

Chain	Residue	Details
E	ASN25
W	ASN25
W	ASN111
W	ASN255
E	ASN111
E	ASN255
K	ASN25
K	ASN111
K	ASN255
Q	ASN25
Q	ASN111
Q	ASN255

---

site_id	SWS_FT_FI4
Number of Residues	8
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
E	ASN78
E	ASN295
K	ASN78
K	ASN295
Q	ASN78
Q	ASN295
W	ASN78
W	ASN295

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16894147, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:23302862

Chain	Residue	Details
E	ASN215
K	ASN215
Q	ASN215
W	ASN215

---

Catalytic Information from CSA

site_id	MCSA1
Number of Residues
Details	M-CSA 246

Chain

Residue

Details

---

site_id	MCSA2
Number of Residues
Details	M-CSA 246

Chain

Residue

Details

---

site_id	MCSA3
Number of Residues
Details	M-CSA 246

Chain

Residue

Details

---

site_id	MCSA4
Number of Residues
Details	M-CSA 246

Chain

Residue

Details

---