7MQS

The insulin receptor ectodomain in complex with three venom hybrid insulin molecules - asymmetric conformation

Summary for 7MQS

Entry DOI	10.2210/pdb7mqs/pdb
Related	7MQO 7MQR
EMDB information	23951
Descriptor	Isoform Short of Insulin receptor, Insulin A chain, Insulin B chain (3 entities in total)
Functional Keywords	insulin, receptor, venom, cone snail, hormone, toxin
Biological source	Homo sapiens (Human) More
Total number of polymer chains	8
Total formula weight	225087.56
Authors	Blakely, A.D.,Xiong, X.,Kim, J.H.,Menting, J.,Schafer, I.B.,Schubert, H.L.,Agrawal, R.,Gutmann, T.,Delaine, C.,Zhang, Y.,Artik, G.O.,Merriman, A.,Eckert, D.,Lawrence, M.C.,Coskun, U.,Fisher, S.J.,Forbes, B.E.,Safavi-Hemami, H.,Hill, C.P.,Chou, D.H.C. (deposition date: 2021-05-06, release date: 2022-03-16, Last modification date: 2023-03-29)
Primary citation	Xiong, X.,Blakely, A.,Kim, J.H.,Menting, J.G.,Schafer, I.B.,Schubert, H.L.,Agrawal, R.,Gutmann, T.,Delaine, C.,Zhang, Y.W.,Artik, G.O.,Merriman, A.,Eckert, D.,Lawrence, M.C.,Coskun, U.,Fisher, S.J.,Forbes, B.E.,Safavi-Hemami, H.,Hill, C.P.,Chou, D.H. Symmetric and asymmetric receptor conformation continuum induced by a new insulin. Nat.Chem.Biol., 18:511-519, 2022 Cited by PubMed: 35289328 DOI: 10.1038/s41589-022-00981-0 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (4.4 Å)

Structure validation